Seminiferous tubules and daily sperm production in older adult men with varied numbers of Leydig cells.
Seminiferous tubules and daily sperm production in older adult men with varied numbers of Leydig cells.
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具有不同数量 Leydig 细胞的老年男性的曲细精管和每日精子产生量。
DOI：
10.1095/biolreprod36.2.301
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发表时间：
1987
影响因子：
3.6
通讯作者：
Petty,CS
中科院分区：
文献类型：
--
作者：
Neaves,WB;Johnson,L;Petty,CS
之前对成年男性的研究未能揭示睾丸中的间质细胞数量与精子生成率之间的关系，这可能是因为年轻男性体内这些细胞的功能过剩。因此，在50名年龄在50-90岁之间的老年男性中寻找间质细胞数量和精子产生之间的可能关系，在这些人中，间质细胞数量因年龄相关的磨损而枯竭。当这些男性按每名男性间质细胞数量增加分为两组、三组或五组时，这些组之间或组内的每名男性每天的精子产量(DSP)、生精小管体积、直径或长度以及生精上皮体积都没有发现差异。此外，在这50名男性中，没有检测到间质细胞数量与DSP之间的显著相关性。间质细胞数量和精子发生之间的唯一关系似乎是阈值效应，因为少于6000万个间质细胞的男性(在本研究中为4个)显著降低了DSP。间质细胞较少的男性往往有较大的间质细胞，大小增加是由于更多的细胞质而不是核质。人间质细胞胞浆总数与DSP、间质细胞平均大小与DSP呈弱而显著的正相关。这些发现表明，在老年男性存活的间质细胞中，精子产量可能与含有产生睾酮的细胞器的细胞质数量之间存在关系。
Previous studies of adult men have failed to reveal a relationship between numbers of Leydig cells in the testes and rates of sperm production, perhaps because of a functional excess of these cells in younger men. Hence, a possible relationship between Leydig cell numbers and sperm production was sought in 50 older men, aged 50–90 years, in whom the Leydig cell population had been depleted by age-related attrition. When these men were sorted by increasing numbers of Leydig cells per man into two, three, or five groups, no difference could be found between or within these groups when daily sperm production per man (DSP); seminiferous tubular volume, diameter, or length; or seminiferous epithelial volume was examined. Furthermore, no significant correlation could be detected between Leydig cell numbers and DSP in these 50 men. The only relationship between numbers of Leydig cells and spermatogenesis appeared to be a threshold effect, in that men with fewer than 60 million Leydig cells (4 in this study) had drastically reduced DSP. Men with few Leydig cells tended to have larger Leydig cells, and the increased size was due to more cytoplasm instead of nucleoplasm. There were weak but significant positive correlations between total Leydig cell cytoplasm per man and DSP and between average size of a Leydig cell and DSP. These findings suggest that a relationship may exist between sperm production and the amount of cytoplasm containing testosterone-producing organelles in surviving Leydig cells of older men.