A latent class model for bivariate binary responses from twins
A latent class model for bivariate binary responses from twins
复制标题
DOI：
10.1111/j.1467-9876.2011.01034.x
复制
发表时间：
2012-01-01
影响因子：
1.6
通讯作者：
Smith, Peter W. F.
中科院分区：
文献类型：
--
作者：
Ekholm, Anders;Jokinen, Jukka;Smith, Peter W. F.
我们提出了一个来自同卵和异卵双胞胎对的双变量二元反应的潜在类模型。我们研究了两种疾病的共病，其中每种疾病及其关联都被推定为通过潜在的易感性而有遗传关联。每个双胞胎都属于四个潜在类别中的一个，被概念化为一个2X2表格，并由两个遗传倾向的概率和它们之间的依赖比来参数化。单合子对的两个成员都属于相同的潜伏类，但双合子对属于四个单独类交叉分类的4X4细胞中的一个。4X4表中的关联结构也通过依赖比进行了参数化。模型的所有参数都是具有明确解释的概率或概率比率，例如流行率和外显率。我们提出了一个由四个潜在类别组成的复合体遗传力的测量方法，它对比了同卵双胞胎和异卵双胞胎的一致性。我们重新分析了两个数据集，并将我们的模型与以前使用的基于其他关联度量的模型进行了比较。
We propose a latent class model for bivariate binary responses from monozygotic and dizygotic twin pairs. We study the comorbidity of two diseases, where each disease and their association are presumed to be genetically related via latent predispositions. Each twin belongs to one of four latent classes, conceptualized as a 2X2 table and parameterized by the probabilities for the two genetic predispositions and the dependence ratio between them. Both members of a monozygotic pair belong to the same latent class, but a dizygotic pair falls in one of the 4X4 cells from the cross-classification of the four individual classes. The association structure in the 4X4 table is also parameterized by dependence ratios. All parameters of the model are probabilities or ratios of probabilities having clear-cut interpretations, e.g. prevalence and penetrance. We propose a measure of heritability of the complex consisting of the four latent classes which contrasts the concordance of monozygotic and dizygotic twins. We reanalyse two data sets and compare our model with previously used models which are based on other measures of association.