Role of TRP ion channels in cerebral circulation and neurovascular communication.
Role of TRP ion channels in cerebral circulation and neurovascular communication.
复制标题
DOI：
10.1016/j.neulet.2021.136258
复制
发表时间：
2021-11-20
影响因子：
2.5
通讯作者：
Sonkusare SK
中科院分区：
文献类型：
--
作者：
Kuppusamy M;Ottolini M;Sonkusare SK
血流的动态调节对于满足大脑的高代谢需求和维持大脑功能至关重要。脑血流量主要由1）决定血管收缩性的内在机制和2）来自神经元和星形胶质细胞的改变血管收缩性的信号调节。来自神经元和星形胶质细胞的刺激也可以在脑毛细血管内皮中启动信号级联以增加局部血流量。最近的研究提供证据表明，内皮细胞、平滑肌细胞、神经元、星形胶质细胞和血管周围神经中的TRP通道控制脑血管收缩和脑血流量。TRP通道通过细胞膜去极化或作为Ca2+内流途径发挥其功能作用。内皮细胞和星形胶质细胞也维持血脑屏障的完整性。内皮细胞和星形胶质细胞都表达TRP通道，内皮TRP通道活性的增加与内皮屏障功能的破坏有关。因此，TRP通道可以在调节血脑屏障完整性方面发挥潜在的重要作用。本文综述了TRP通道在健康和疾病状态下对脑血管收缩力的调节及其在维持血脑屏障功能中的潜在作用。
The dynamic regulation of blood flow is essential for meeting the high metabolic demands of the brain and maintaining brain function. Cerebral blood flow is regulated primarily by 1) the intrinsic mechanisms that determine vascular contractility and 2) signals from neurons and astrocytes that alter vascular contractility. Stimuli from neurons and astrocytes can also initiate a signaling cascade in the brain capillary endothelium to increase regional blood flow. Recent studies provide evidence that TRP channels in endothelial cells, smooth muscle cells, neurons, astrocytes, and perivascular nerves control cerebrovascular contractility and cerebral blood flow. TRP channels exert their functional effects either through cell membrane depolarization or by serving as a Ca2+ influx pathway. Endothelial cells and astrocytes also maintain the integrity of the blood-brain barrier. Both endothelial cells and astrocytes express TRP channels, and an increase in endothelial TRP channel activity has been linked with a disrupted endothelial barrier function. Therefore, TRP channels can play a potentially important role in regulating blood-brain barrier integrity. Here, we review the regulation of cerebrovascular contractility by TRP channels under healthy and disease conditions and their potential roles in maintaining blood-brain barrier function.
登录
查看更多内容
影响因子：
4.3
作者：
Chen J;Li Z;Hatcher JT;Chen QH;Chen L;Wurster RD;Chan SL;Cheng Z
通讯作者：
Cheng Z
DOI：
10.1523/jneurosci.6451-10.2011
发表时间：
2011-03-30
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cavanaugh DJ;Chesler AT;Jackson AC;Sigal YM;Yamanaka H;Grant R;O'Donnell D;Nicoll RA;Shah NM;Julius D;Basbaum AI
通讯作者：
Basbaum AI
影响因子：
3.4
作者：
Bobkov, Y. V.;Corey, E. A.;Ache, B. W.
通讯作者：
Ache, B. W.
影响因子：
5.3
作者：
Dietrich, A;Schnitzler, MMY;Birnbaumer, L
通讯作者：
Birnbaumer, L
影响因子：
4.6
作者：
Cozart, Michael A.;Phelan, Kevin D.;Zheng, Fang
通讯作者：
Zheng, Fang