Prevalence of non-alcoholic fatty liver disease: population based study
Prevalence of non-alcoholic fatty liver disease: population based study
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DOI：
10.1016/s1665-2681(19)31922-2
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发表时间：
2007-07-01
影响因子：
3.8
通讯作者：
Deshpande, Anjali
中科院分区：
文献类型：
--
作者：
Amarapurkar, Deepak;Kamani, Prafull;Deshpande, Anjali
背景与目的：非酒精性脂肪性肝病（NAFLD）在西方国家是慢性肝病和肝移植的常见病因。在日本和中国等亚洲国家，NAFLD的发病率越来越高。糖尿病（DM）、肥胖、高胰岛素血症是NAFLD的易感因素。在过去二十年中，印度糖尿病、肥胖和胰岛素抵抗的发病率有所增加。因此，预期印度NAFLD发病率增加是合乎逻辑的。关于印度NAFLD患病率的数据有限。大多数数据来自基于医院的研究，包括少数患者。因此，本研究计划估计NAFLD在一般人群中的患病率。材料与方法：对两个铁路殖民地居民进行病史、临床检查、人体测量、生化检查和腹部超声检查。结果：1168名参与者被评估。排除了任何饮酒量、HBs Ag阳性、抗HCV阳性、患有其他已知肝脏疾病和服用导致肝脏疾病的药物的人。超声检查NAFLD的患病率为16.6%。在730名20岁以上的受试者中（男性341人，女性389人），平均年龄39.08 ~ 12.3岁，4%患有糖尿病，57%患有中心性肥胖。20岁以上人群超声检查NAFLD患病率为18.9%。NAFLD在男性中的患病率高于女性（24.6%比13.6%,p 0.001）。与NAFLD相关的危险因素为年龄大于40岁、男性、中心性肥胖、BMR偏高、空腹血糖升高、AST和ALT升高。结论：印度人群NAFLD患病率与西方相当。
Background and aim: Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and liver transplantation in western countries. Increasing incidence of NAFLD has been well documented from Asian countries like Japan and China. Diabetes mellitus (DM), obesity, hyperinsulinemia are predisposing factors for NAFLD. There is increase in incidence of DM, obesity and insulin resistance in India in last two decades. Hence it is logical to expect increase in incidence of NAFLD in India. There is limited data on the prevalence of NAFLD from India. Majority of data comes from hospital based studies including small number of patients. Therefore this study was planned to estimate the prevalence of NAFLD in general population. Material and methods: Residents of two Railway colonies were evaluated on history, clinical examination, anthropometric measurements, biochemical tests and abdominal ultrasound. Results: 1,168 participants were evaluated. Persons with any amount of alcohol consumption, HBs Ag positive, Anti HCV positive, persons with other known liver diseases and taking medications causing liver disease were excluded. Prevalence of NAFLD on ultrasound was 16.6%. Out of 730 subjects above the age of 20 years (341 male 384 female 389) mean age 39.08 12.3 years, 4% had diabetes, 57% had central obesity. Prevalence of NAFLD based on the ultrasound above 20 years of age was 18.9%. NAFLD was more prevalent in male than female (24.6% vs 13.6%, p 0.001). Risk factors associated with NAFLD were age more than 40 years, male gender, central obesity, high BMR > 25, elevated fasting blood sugar, raised AST and ALT. Conclusion: Prevalence of NAFLD in Indian population is comparable to the west.