Latent Toxoplasma gondii infection leads to improved action control
Latent Toxoplasma gondii infection leads to improved action control
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DOI：
10.1016/j.bbi.2013.11.004
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发表时间：
2014-03
期刊：
影响因子：
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通讯作者：
A. Stock;E. H. Heinegg;H. Köhling;C. Beste
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文献类型：
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作者：
A. Stock;E. H. Heinegg;H. Köhling;C. Beste
寄生虫刚地弓形虫（Toxoplasma gondii）已被发现操纵其次级宿主的行为以增加其自身的传播，这通常被认为是对宿主的损害（操纵假说）。该操作与多巴胺能神经传递的上调相关。在人类中，不同的病理与T。但大多数潜伏感染的人似乎没有表现出明显的损伤。由于多巴胺加不一定只对人类产生负面影响，我们研究了潜伏性弓形虫病（以及推测的多巴胺能神经传递增强）对人类认知和行为的潜在积极影响。为此，我们专注于行动级联已被证明是由多巴胺调制。基于通过停止变化范式获得的行为和神经生理学（EEG）数据，我们能够证明健康的年轻人实际上可以从latentT中受益。关于它们在该任务中的表现（如由更快的响应时间和更小的P3分量所指示的）。数据表明，一种被认为影响多巴胺能系统的潜伏感染可能导致人类认知控制过程的矛盾改善。
The parasiteToxoplasma gondiihas been found to manipulate the behavior of its secondary hosts to increase its own dissemination which is commonly believed to be to the detriment of the host (manipulation hypothesis). The manipulation correlates with an up-regulation of dopaminergic neurotransmission. In humans, different pathologies have been associated withT. gondiiinfections but most latently infected humans do not seem to display overt impairments. Since a dopamine plus does not necessarily bear exclusively negative consequences in humans, we investigated potential positive consequences of latent toxoplasmosis (and the presumed boosting of dopaminergic neurotransmission) on human cognition and behavior. For this purpose, we focused on action cascading which has been shown to be modulated by dopamine. Based on behavioral and neurophysiological (EEG) data obtained by means of a stop–change paradigm, we were able to demonstrate that healthy young humans can actually benefit from latentT. gondiiinfection as regards their performance in this task (as indicated by faster response times and a smaller P3 component). The data shows that a latent infection which is assumed to affect the dopaminergic system can lead to paradoxical improvements of cognitive control processes in humans.