Caffeine, but not nicotine, enhances visual feature binding
Caffeine, but not nicotine, enhances visual feature binding
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DOI：
10.1111/j.1460-9568.2005.03868.x
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发表时间：
2005-01-01
影响因子：
3.4
通讯作者：
Hommel, B
中科院分区：
文献类型：
--
作者：
Colzato, LS;Fagioli, S;Hommel, B
人类视觉皮层的分布式组织需要一种机制来整合和绑定感知事件的特征，而神经同步是服务于这一目的的主要候选者。动物研究表明，视觉皮层的同步被毒蕈碱胆碱能系统增强。在这里，我们表明，在健康的人类中，视觉对象的形状和颜色以及形状和位置的结合通过刺激毒蕈碱胆碱能系统（咖啡因消耗）而不是通过刺激尼古丁胆碱能系统（尼古丁消耗）而增加。感知和行动之间的结合不受任何操纵的影响，这表明视觉系统和毒蕈碱胆碱能系统之间存在特定的联系。
The distributed organization of the human visual cortex calls for a mechanism that integrates and binds the features of a perceived event, and neural synchronization is a prime candidate to serve that purpose. Animal studies suggest that synchronization in the visual cortex is enhanced by the muscarinic cholinergic system. Here we show that in healthy humans the binding of shape and colour, and of shape and location, of visual objects is increased by stimulating the muscarinic cholinergic system (caffeine consumption) but not by stimulating the nicotinic cholinergic system (nicotine consumption). Binding across perception and action is unaffected by either manipulation, suggesting a specific link between the visual system and the muscarinic cholinergic system.