Epidemiology of insulin-like growth factor-I in elderly men and women - The Rancho Bernardo Study
Epidemiology of insulin-like growth factor-I in elderly men and women - The Rancho Bernardo Study
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DOI：
10.1093/oxfordjournals.aje.a009065
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发表时间：
1997-06-01
影响因子：
5
通讯作者：
BarrettConnor, E
中科院分区：
文献类型：
--
作者：
GoodmanGruen, D;BarrettConnor, E
胰岛素样生长因子-1 （IGF-I）在血液循环中含量丰富，已被证明具有广泛的生物效应。作者对年龄在50-97岁之间的420名男性和419名未使用雌激素的绝经后妇女进行了一项基于社区的横断面研究，以确定IGF-I测量的个人和实验室可靠性，以及IGF-I与常见流行病学混杂因素的关联。没有季节或日变化的证据。igf - 1在两性中随年龄呈线性下降，男性显著低于女性（126.9 μ g/l vs. 134.1 μ g/l； P=0.03）。在年龄调整分析中，igf - 1与身高、总脂肪或中心脂肪、瘦体重、当前吸烟、体育活动或常用药物无关。相比之下，在报告饮酒的男性和女性中，igf - 1水平明显高于报告不饮酒的男性和女性，并且酒精作为一个连续变量在男性中显示出显著的正线性趋势（p=0.0007）。作者得出结论，igf - 1仅与年龄、性别和酒精使用有关。最小的混杂变量，良好的可靠性，和小的个体差异表明，igf - 1应该适用于流行病学研究。
Insulin-like growth factor-1 (IGF-I) is abundant in the circulation and has been shown to have a wide array of biologic effects. The authors carried out a cross-sectional community-based study of 420 men and 419 nonestrogen-using postmenopausal women aged 50-97 years to ascertain the within-person and laboratory reliability of IGF-I measurements, and the association of IGF-I with common epidemiologic con confounders. There was no evidence of seasonal or diurnal variation. IGF-I decreased linearly with age in both sexes, with significantly lower levels in men than women (126.9 mu g/liter vs. 134.1 mu g/liter; P=0.03). In age-adjusted analyses, IGF-I was not associated with height, total or central body fat, lean body mass, current smoking, physical activity, or commonly used medications. By contrast, in both men and women who reported any alcohol use, IGF-I levels were significantly higher compared with those in men and women who reported no alcohol use, and alcohol as a continuous variable showed a significant positive linear trend in men (p=0.0007). The authors conclude that IGF-I varied significantly only with age, sex, and alcohol use. The minimal number of confounding variables, good reliability, and little intraindividual variation suggest that IGF-I should be suitable for epidemiologic research.