Immunity around the clock.
Immunity around the clock.
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全天候免疫。
DOI：
10.1126/science.aah4966
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发表时间：
2016-11-25
期刊：
影响因子：
--
通讯作者：
Chawla A
中科院分区：
文献类型：
--
作者：
Man K;Loudon A;Chawla A
免疫力是一种高成本、高效益的特性，可以抵御病原体和有害刺激，但其过度激活可能导致免疫病理学，有时甚至死亡。由于许多免疫参数根据一天中的时间有节奏地振荡，生物钟已成为降低免疫相关成本的重要守门人，这反过来又增强了生物体的适应性。这是由外在环境线索和免疫细胞的内在振荡器之间的相互作用介导的，它们共同优化了整个昼夜节律周期的免疫反应。阐明这些时钟控制的免疫调节机制可能会发现治疗感染和慢性炎症性疾病的新方法。
Immunity is a high-cost, high-benefit trait that defends against pathogens and noxious stimuli, but whose overactivation can result in immunopathologies and sometimes even death. Because many immune parameters oscillate rhythmically based on the time of day, the circadian clock has emerged as an important gatekeeper for reducing immunity-associated costs, which, in turn, enhances organismal fitness. This is mediated by interactions between the extrinsic environmental cues and the intrinsic oscillators of immune cells, which together optimize immune responses throughout the circadian cycle. The elucidation of these clock-controlled immunomodulatory mechanisms might uncover new approaches for treating infections and chronic inflammatory diseases.