Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α.
Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α.
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DOI：
10.1038/mp.2015.67
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发表时间：
2016-05
影响因子：
11
通讯作者：
Mondelli V
中科院分区：
文献类型：
--
作者：
Baumeister D;Akhtar R;Ciufolini S;Pariante CM;Mondelli V
童年创伤赋予成年期身体和精神疾病的风险更高;然而，介导这种关联的生物学机制在很大程度上仍然未知。最近的研究表明，免疫系统的失调可能是一种生物介质。本文进行了一项荟萃分析，以确定早期生活逆境是否有助于成年个体中潜在的致病性促炎表型。Pubmed、PsycINFO、EMBASE、Scopus和Medline的系统检索确定了25篇用于荟萃分析的文章，包括18项研究，包括16 870例C反应蛋白（CRP）样本，15项研究，包括3751例白细胞介素-6（IL-6）样本，10项研究，包括881例肿瘤坏死因子-α（TNF-α）样本。随机效应荟萃分析显示，暴露于儿童期创伤的个体具有显著升高的CRP（Fisher's z=0.10，95%置信区间（CI）=0.05-0.14）、IL-6（z=0.08，95% CI=0.03-0.14）和TNF-α（z=0.23，95% CI=0.14-0.32）的基线外周水平。对特定类型创伤（性虐待、身体虐待或情感虐待）的亚组分析显示，这些创伤对单一炎症标志物的影响不同。此外，荟萃回归显示，儿童创伤与CRP之间的相关性在临床样本中的效应量更大，但与IL-6或TNF-α无关。年龄、体重指数（BMI）和性别没有调节作用。分析表明，童年创伤有助于成年后的促炎状态，具体的炎症特征取决于特定类型的创伤。
Childhood trauma confers higher risk of adulthood physical and mental illness; however, the biological mechanism mediating this association remains largely unknown. Recent research has suggested dysregulation of the immune system as a possible biological mediator. The present paper conducted a meta-analysis to establish whether early-life adversity contributes to potentially pathogenic pro-inflammatory phenotypes in adult individuals. A systematic search of Pubmed, PsycINFO, EMBASE, Scopus and Medline identified 25 articles for the meta-analysis, including 18 studies encompassing a sample of 16 870 individuals for C-reactive protein (CRP), 15 studies including 3751 individuals for interleukin-6 (IL-6) and 10 studies including 881 individuals for tumour necrosis factor-α (TNF-α). Random-effects meta-analysis showed that individuals exposed to childhood trauma had significantly elevated baseline peripheral levels of CRP (Fisher's z=0.10, 95% confidence interval (CI)=0.05–0.14), IL-6 (z=0.08, 95% CI=0.03–0.14) and TNF-α (z=0.23, 95% CI=0.14–0.32). Subgroup analyses for specific types of trauma (sexual, physical or emotional abuse) revealed that these impact differentially the single inflammatory markers. Moreover, meta-regression revealed greater effect sizes in clinical samples for the association between childhood trauma and CRP but not for IL-6 or TNF-α. Age, body mass index (BMI) and gender had no moderating effects. The analysis demonstrates that childhood trauma contributes to a pro-inflammatory state in adulthood, with specific inflammatory profiles depending on the specific type of trauma.