Priming B cell-mediated anti-HIV envelope responses by vaccination allows for the long-term control of infection in macaques exposed to a R5-tropic SHIV
Priming B cell-mediated anti-HIV envelope responses by vaccination allows for the long-term control of infection in macaques exposed to a R5-tropic SHIV
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DOI：
10.1016/j.virol.2003.12.003
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发表时间：
2004-03-01
期刊：
影响因子：
3.7
通讯作者：
Stamatatos, L
中科院分区：
文献类型：
--
作者：
Buckner, C;Gines, LG;Stamatatos, L
通过用HIV包膜蛋白免疫猕猴并在用致病性嗜CCR 5的SIV/HIV嵌合病毒SHIVSF 162 P4静脉内攻击之前瞬时耗尽它们的CD 8+细胞来评价疫苗引发的抗HIV包膜抗体控制HIV感染的潜力。尽管未达到灭菌免疫，但所有接种动物均有效控制了感染，并在观察期间（超过3年）保持无疾病。相反，在同一时期，对照动物进展为疾病。接种者和对照组在感染后都产生了强有力的细胞介导的抗病毒和中和抗体应答。对这些反应的比较分析表明，接种疫苗的动物对感染的长期控制更有效，这是由于抗HIV包膜抗体的产生更快。这些研究表明，通过接种B细胞抗HIV包膜应答的引发对于HIV感染的长期控制可能是至关重要的。(C)2004年爱思唯尔公司All rights reserved.
The potential of vaccine-elicited anti-HIV envelope antibodies to control HIV-infection was evaluated by immunizing macaques with the HIV envelope protein and transiently depleting them of their CD8+ cells before intravenous challenge with the pathogenic CCR5-tropic SIV/HIV chimeric virus, SHIVSF162P4. Although sterilizing immunity was not achieved, all vaccinated animals effectively controlled infection and remained free of disease for the duration of observation (over 3 years). In contrast, during the same period, the control animals progressed to disease. Both the vaccinees and the controls developed robust cell-mediated antiviral and neutralizing antibody responses following infection. A comparative analysis of these responses suggests that the more effective long-term control of infection by the vaccinated animals is due to the more rapid development of anti-HIV envelope antibodies. These studies suggest that priming by vaccination of B cell anti-HIV envelope responses maybe crucial for the long-term control of HIV infection. (C) 2004 Elsevier Inc. All rights reserved.