The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease
The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease
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DOI：
10.1155/2020/3467419
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发表时间：
2020-06-22
影响因子：
2
通讯作者：
Huang, Zhi-Ming
中科院分区：
文献类型：
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作者：
Chen, Yi-Han;Wang, Li;Huang, Zhi-Ming
目标。本研究的目的是评估炎症性肠病 (IBD) 患者的 C 反应蛋白/白蛋白比 (CRP/ALB)、炎症标志物和全血细胞计数 (CBC) 参数及其与疾病活动性的关系。方法。本回顾性研究共纳入 876 例 IBD 患者，其中 275 例溃疡性结肠炎（UC）患者和 601 例克罗恩病（CD）患者，测量了血清 C 反应蛋白（CRP）、白蛋白（ALB）、红细胞沉降率（ESR）和 CBC 参数。为了探索疾病活动性，梅奥评分和克罗恩病活动指数分别用于评估 UC 和 CD 患者。结果。活动性IBD患者CRP/ALB比值、CRP、ESR、血小板与淋巴细胞比值（PLR）、红细胞分布宽度（RDW）、中性粒细胞与淋巴细胞比值（NLR）水平显着高于非活动性IBD患者，而ALB和淋巴细胞与单核细胞比值（LMR）水平显着降低（P < 0.001）。受试者工作特征分析显示，活动性UC和CD的CRP/ALB比值最佳截断值为0.18和0.43，敏感性分别为67.8%和75.8%，特异性为86.7%和92.0%。多变量逻辑分析显示，调整这些炎症标志物（ESR、NLR、PLR 和 LMR）后，CRP/ALB 比值是能够区分 UC 和 CD 疾病活动性的具有统计学意义的参数。结论。本研究表明CRP/ALB比值与IBD疾病活动度密切相关。与CBC参数相比，CRP/ALB比值对活动性IBD具有更高的判别能力。
Objectives. The aims of this study were to evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers, and parameters from the complete blood count (CBC) in patients with inflammatory bowel disease (IBD) and their associations with disease activity. Methods. A total of 876 IBD patients, composed of 275 patients with ulcerative colitis (UC) and 601 patients with Crohn's disease (CD), were included in this retrospective study, and the serum C-reactive protein (CRP), albumin (ALB), erythrocyte sedimentation rate (ESR), and CBC parameters were measured. To explore the disease activity, the Mayo score and Crohn disease activity index were used to assess UC and CD patients, respectively. Results. The CRP/ALB ratio, CRP, ESR, platelet to lymphocyte ratio (PLR), red blood cell distribution width (RDW), and neutrophil to lymphocyte ratio (NLR) levels in active IBD patients were significantly higher than those in inactive IBD patients, whereas ALB and lymphocyte to monocyte ratio (LMR) levels were significantly decreased (P < 0.001). The receiver operating characteristic analysis showed that the optimum cut-off values of the CRP/ALB ratio for active UC and CD were 0.18 and 0.43, with sensitivities of 67.8% and 75.8% and specificities of 86.7% and 92.0%, respectively. Multivariable logistic analysis revealed that after adjusting for these inflammatory markers (ESR, NLR, PLR, and LMR), the CRP/ALB ratio was a statistically significant parameter capable of differentiating the disease activity of UC and CD. Conclusions. This study indicated that the CRP/ALB ratio was closely related to the IBD disease activity. Compared with CBC parameters, the CRP/ALB ratio had a higher discriminative capacity for active IBD.