Age related changes of the extracellular matrix and stem cell maintenance
Age related changes of the extracellular matrix and stem cell maintenance
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DOI：
10.1016/j.ypmed.2012.01.003
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发表时间：
2012-05-01
影响因子：
5.1
通讯作者：
Oh, Su-Jun
中科院分区：
文献类型：
--
作者：
Kurtz, Andreas;Oh, Su-Jun
衰老的特征是组织和器官功能、再生能力降低，并伴随着组织驻留干细胞数量减少和效力丧失。衰老对干细胞群体的影响在组织之间不同，并且取决于许多非细胞内在因素，包括与免疫系统改变相关的全身变化，以及局部细胞结构的衰老相关变化。后者已被研究的背景下所需的干细胞维护的环境生态位属性。在这里，我们将讨论细胞外基质（ECM）对干细胞维持的影响，其在衰老过程中的变化及其对干细胞治疗的意义。我们提供了一个概述ECM成分和年龄相关的细胞结构重塑的例子。将描述干细胞与ECM的相互作用，并概述完整且适宜的ECM对于干细胞维持、分化和干细胞启动的组织修复的重要性。可以得出结论，由于年龄相关的炎症，纤维化或氧化应激重塑ECM提供了内源性再生或干细胞治疗的环境不足。提供足够的ECM干细胞治疗和内源性再生和抗氧化剂的潜力，以防止ECM损伤，促进其修复，并随后支持再生的手段进行了讨论。(C)2012 Elsevier Inc. All rights reserved.
Aging is characterized by reduced tissue and organ function, regenerative capacity, and accompanied by a decrease in tissue resident stem cell numbers and a loss of potency. The impact of aging on stem cell populations differs between tissues and depends on a number of non cell-intrinsic factors, including systemic changes associated with immune system alterations, as well as senescence related changes of the local cytoarchitecture. The latter has been studied in the context of environmental niche properties required for stem cell maintenance. Here, we will discuss the impact of the extracellular matrix (ECM) on stem cell maintenance, its changes during aging and its significance for stem cell therapy. We provide an overview on ECM components and examples of age associated remodeling of the cytoarchitecture. The interaction of stem cells with the ECM will be described and the importance of an intact and hospitable ECM for stem cell maintenance, differentiation and stem cell initiated tissue repair outlined. It is concluded that a remodeled ECM due to age related inflammation, fibrosis or oxidative stress provides an inadequate environment for endogenous regeneration or stem cell therapies. Means to provide adequate ECM for stem cell therapies and endogenous regeneration and the potential of antioxidants to prevent ECM damage and promote its repair and subsequently support regeneration are discussed. (C) 2012 Elsevier Inc. All rights reserved.