Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages
Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages
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DOI：
10.1016/j.jneuroim.2008.07.015
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发表时间：
2008-11-15
影响因子：
3.3
通讯作者：
Hellings, Niels
中科院分区：
文献类型：
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作者：
Hendriks, Jerome J. A.;Slaets, Helena;Hellings, Niels
白血病抑制因子(LIF)在中枢神经系统(CNS)的自身免疫和损伤反应中促进神经胶质细胞和神经元的存活。虽然各种研究表明，LIF也调节正在进行的炎症反应，但缺乏关于潜在事件的数据。在这项研究中，我们证明了LIF调节巨噬细胞的功能。LiF抑制氧自由基和肿瘤坏死因子α的产生，并刺激巨噬细胞摄取髓鞘。LIF的这些作用伴随着JAK/STAT3信号通路的激活。我们的研究结果表明，LIF具有抗炎作用和促进髓鞘清除的作用，提示LIF可能是中枢神经系统炎症性疾病的一个重要因素。(C)2008爱思唯尔B.V.保留所有权利。
Leukemia inhibitory factor (LIF) promotes survival of glial cells and neurons during autoimmune and injury responses in the central nervous system (CNS). While various Studies indicate that LIF also modulates ongoing inflammatory responses, data on underlying events are lacking. In this study we demonstrate that LIF modulates macrophage function. LIF inhibits the production of oxygen radicals and TNFalpha and stimulates myelin uptake by macrophages. These effects of LIF are accompanied by activation of the JAK/STAT3 signalling pathway. Our findings demonstrate that LIF has anti-inflammatory properties and enhances myelin clearance, implicating that LIF may be an important factor in CNS inflammatory disease. (C) 2008 Elsevier B.V. All rights reserved.