RATES OF SPONTANEOUS MUTATION AMONG RNA VIRUSES
RATES OF SPONTANEOUS MUTATION AMONG RNA VIRUSES
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DOI：
10.1073/pnas.90.9.4171
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发表时间：
1993-05-01
影响因子：
11.1
通讯作者：
DRAKE, JW
中科院分区：
文献类型：
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作者：
DRAKE, JW
简单的方法来估计自发突变率的突变频率和人口参数的RNA病毒。已发表的突变频率产生了每个基因组每次复制的突变率范围很广，这主要是因为突变靶通常很小，因此平均碱基的突变性样本很差。然而，裂解性RNA病毒（噬菌体Q β、脊髓灰质炎、水疱性口炎和甲型流感）有一个明显的集中趋势，显示出几乎等于每个基因组每次复制1个的自发突变率。这一比率比以前报道的基于DNA的微生物高300倍。因此，裂解性RNA病毒以接近与存活力相容的最大值的速率突变。然而，逆转录病毒（脾坏死、鼠白血病、劳斯肉瘤）的平均突变率比裂解性RNA病毒低一个数量级。
Simple methods are presented to estimate rates of spontaneous mutation from mutant frequencies and population parameters in RNA viruses. Published mutant frequencies yield a wide range of mutation rates per genome per replication, mainly because mutational targets have usually been small and, thus, poor samples of the mutability of the average base. Nevertheless, there is a clear central tendency for lytic RNA viruses (bacteriophage Qbeta, poliomyelitis, vesicular stomatitis, and influenza A) to display rates of spontaneous mutation of almost-equal-to 1 per genome per replication. This rate is some 300-fold higher than previously reported for DNA-based microbes. Lytic RNA viruses thus mutate at a rate close to the maximum value compatible with viability. Retroviruses (spleen necrosis, murine leukemia, Rous sarcoma), however, mutate at an average rate about an order of magnitude lower than lytic RNA viruses.