TCR antagonism and T cell tolerance can be independently induced in a DR-restricted, hemagglutinin-specific T cell clone.
TCR antagonism and T cell tolerance can be independently induced in a DR-restricted, hemagglutinin-specific T cell clone.
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TCR 拮抗作用和 T 细胞耐受性可以在 DR 限制的血凝素特异性 T 细胞克隆中独立诱导。
DOI：
10.1093/intimm/6.3.363
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发表时间：
1994
影响因子：
4.4
通讯作者：
Sette,A
中科院分区：
文献类型：
--
作者：
Alexander,J;Ruppert,J;Snoke,K;Sette,A
TCR与肽-MHC结合的结果对于宿主的免疫应答具有核心重要性。TCR拮抗作用是一种已知的现象，其特征在于通过非刺激性抗原类似物选择性抑制T细胞应答。T细胞无反应性是导致T细胞无反应的另一种状态，通常以缺乏增殖和淋巴细胞产生为特征。在本研究中，TCR拮抗和T细胞无能之间的关系进行了检查，通过使用已知的协议，以诱导任一现象。再分离实验表明，拮抗的T细胞不耐受，因为它们完全能够响应随后的抗原攻击。相反，虽然高剂量的可溶性抗原可以有效地诱导T细胞耐受性，但TCR拮抗剂单独或与次优抗原剂量结合不能。总之，这些数据表明TCR拮抗作用和T细胞耐受性是彼此独立的现象。
The outcome of TCR engagement with peptide-MHC Is of central Importance for the immune response of the host. TCR antagonism is one phenomenon known which is characterized by selective inhibition of T cell responses by non-stimulatory antigen analogs. T cell anergy Is another state resulting in T cell unresponslveness, generally characterized by lack of proliferation and lymphoklne production. In the present study, the relationship between TCR antagonism and T cell anergy was examined by using protocols known to induce either phenomenon. Re-Isolation experiments demonstrated that antagonized T cells were not tolerized, in that they were fully capable of responding to a subsequent antigen challenge. Conversely, while high doses of soluble antigen could efficiently induce T cell tolerance, TCR antagonists, either alone or in conjunction with suboptimal antigen doses, could not. Taken together, these data demonstrate that TCR antagonism and T cell tolerance are phenomena independent of each other.