Decreased incidence of VanA-type vancomycin-resistant enterococci isolated from poultry meat and from fecal samples of humans in the community after discontinuation of avoparcin usage in animal husbandry
Decreased incidence of VanA-type vancomycin-resistant enterococci isolated from poultry meat and from fecal samples of humans in the community after discontinuation of avoparcin usage in animal husbandry
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DOI：
10.1089/mdr.1999.5.45
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发表时间：
1999-03-01
期刊：
影响因子：
--
通讯作者：
Witte, W
中科院分区：
文献类型：
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作者：
Klare, I;Badstübner, D;Witte, W
1994-1995年，许多欧洲国家在畜牧业中使用糖肽类抗生素阿伏帕素（AVO）作为饲料添加剂，导致在德国（萨克森-安哈尔特州）从商业生产的动物食品以及非住院患者的粪便样本中频繁分离出vana型耐万古霉素肠球菌（VRE）。然而，在1997年底，在德国生产商生产的冷冻和新鲜禽肉（鸡和火鸡）中检测到的此类VRE数量正在减少。此时，AVO在丹麦/挪威已停止在畜牧业中使用超过2年半，在德国已停止使用近2年，在所有欧共体国家和瑞士已分别停止使用约8-9个月。随后，仅在四分之一的家禽肉样本中检测到极低浓度的VRE（31个样本中的8个，来自18个不同的德国生产商，在12个不同的超市购买）。在同一地区（德国萨克森-安哈尔特州），健康人（VRE携带者）肠道菌群中的VRE患病率也有所下降，从1994年使用AVO时的12%（12/100）下降到1996年的6%（6/100）和1997年停用AVO后的3%（13/400）。这些结果可能表明糖肽（如AVO）的抗生素选择压力对商业畜牧业动物肉制品中VRE存在的重要性，此外，它强调了动物产品在社区中耐药细菌和可转移耐药基因向人类传播中的作用。
The use of the glycopeptide antibiotic avoparcin (AVO) as a feed additive in animal husbandry of many European countries led in 1994-1995 to frequent isolation of VanA-type vancomycin-resistant enterococci (VRE) from commercially produced animal foodstuffs as well as from fecal samples of nonhospitalized persons in Germany (Saxony-Anhalt state). However, at the end of 1997, a decreasing number of such VRE was detected in frozen and fresh poultry meat (chickens and turkeys) from German producers. At this point in time, AVO had been discontinued in animal husbandry for more than 2 and one-half years in Denmark/Norway, nearly 2 years in Germany, and about 8-9 months in all countries of the European Community and Switzerland, respectively, VRE were then only detected in very low concentrations in one-quarter of the poultry meat samples (eight of 31, originating from 18 distinct German producers and bought in 12 different supermarkets), A decline of VRE prevalence was also observed in the gut flora of healthy persons (VRE carriers) in the same region (Saxony-Anhalt state, Germany), having fallen from 12% (12/100) in 1994 when AVO was being used to 6% (6/100) in 1996 and 3% (13/400) in 1997 after it was discontinued. These results likely indicate the importance of antibiotic selective pressure by glycopeptides such as AVO for the presence of VRE in animal meat products from commercial animal husbandry, Additionally, it underlines the role of animal products for the spread of resistant bacteria and transferable resistance genes to humans in the community.