[Pharmacological actions of baicalin and baicalein. 2. On passive anaphylaxis].
[Pharmacological actions of baicalin and baicalein. 2. On passive anaphylaxis].
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【黄芩苷和黄芩素的药理作用。
DOI：
10.1254/fpj.66.194
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
H. Wada
中科院分区：
文献类型：
--
作者：
A. Koda;H. Nagai;H. Wada
在中药中，黄芩被用来治疗一些过敏性疾病。为此，作者研究了黄芩苷和黄芩素对豚鼠主动过敏反应的影响，并与芦丁、甲基橙皮苷和槲皮苷进行了比较。1)给予黄芩苷后，主动致敏豚鼠由抗原气雾剂引起的惊厥前发作时间较对照组延迟约3倍，且作用强于芦丁。2)黄芩苷和黄芩素对Schulz-Dale反应有抑制作用，抑制强度由大到小依次为：苷类中，黄芩苷+GT；芦丁+GT；甲基橙皮苷；苷元中，黄芩素+槲皮苷。此外，苷元的作用强于各糖苷。3)在放置致敏回肠和非致敏回肠的器官浴中加入抗原，致敏回肠紧随非致敏回肠收缩而强烈收缩。在此条件下，黄芩苷降低非致敏回肠的收缩，而黄芩素显著降低两者的收缩。4)黄芩苷和黄芩素对豚鼠回肠有轻微的抗组胺和抗胆碱能作用。5)环沉淀试验中，黄芩苷或黄芩素不影响抗原-抗体结合。6)黄芩苷对灌流抗原的豚鼠肺组织中组胺和SRS-A的释放均有抑制作用，且作用比芦丁更显著。7)黄芩苷和黄芩素可抑制豚鼠肺组织组胺和SRS-A的过敏性释放。在相同的摩尔浓度下，它们的抑制活性没有太大差异。但它们既不影响介质释放的破坏，也不抑制介质对回肠的收缩。Ca++的加入不影响黄芩素对介质释放的抑制作用，但半胱氨酸使其抑制作用减弱。
In the Chinese medicine, Scutellaria baicalensis GEORG has been used as a remedy for some of allergic diseases. Therefore, the authors investigated the effects of baicalin and baicalein, components of the drug, on active anaphylactic reaction in guinea pig, and the results obtained were compared with those of rutin, methylhesperidin and quercetin. 1) By the administration of baicalin, the onset of preconvulsion caused by the antigen-aerosol in actively sensitized guinea pig was delayed about 3 times in contrast to the control, and the effect of baicalin was more potent than that of rutin. 2) Baicalin and baicalein inhibited Schulz-Dale reaction in isolated ileum, and the intensity of inhibition was following order; in glycoside, baicalin>rutin>methylhesperidin, and in aglycon, baicalein>quercetin. Futhermore, the effect of aglycone was more potent than that of each glycoside. 3) As the antigen was added to the organ bath which placed sensitized and non-sensitized ileum, sensitized ileum strongly contracted followed by contraction of non-sensitized one. In this condition, baicalin decreased the contraction of non-sensitized ileum, while baicalein strongly decreased those of both ones. 4) Baicalin and baicalein slightly showed antihistaminic and anticholinergic effects on ileum of guinea pig. 5) The antigen-antibody combination was not affected by baicalin or baicalein in ring precipitation test. 6) The release of histamine and SRS-A from sinsitized guinea pig lung which perfused with antigen were decreased by baicalin, and the decreasing activity was more remarkable than that of rutin. 7) Baicalin and baicalein inhibited the anaphylactic release of histamine and SRS-A from chopped tissue of guinea pig lung. There was not much difference between the inhibitory activities of them in a equal molar concentration. However, they neither affected the destruction of mediator released nor inhibited contraction of ileum by mediator. The inhibitory action of baicalein on release of mediator was not affected by the addition of Ca++, but decreased by cysteine.