Interaction of thyroid hormone and retinoic acid receptors on the regulation of the rat growth hormone gene promoter.
Interaction of thyroid hormone and retinoic acid receptors on the regulation of the rat growth hormone gene promoter.
复制标题
甲状腺激素和视黄酸受体的相互作用对大鼠生长激素基因启动子的调节。
DOI：
10.1006/bbrc.1993.1257
复制
发表时间：
1993
影响因子：
3.1
通讯作者：
Aranda,A
中科院分区：
文献类型：
--
作者：
García-Villalba,P;Au-Fliegner,M;Samuels,HH;Aranda,A
视黄酸通过位于生长激素（GH）基因5 ′-侧翼区的序列转录调节该基因的表达。在大鼠GH启动子的− 181 bp处，维甲酸可以部分诱导，而完整的反应需要-209的序列。这些序列包含之前鉴定的甲状腺激素反应元件。类维生素A X受体RXR增加T3和RA的反式激活。类维生素A是相对更有效地刺激天然GH启动子比异源启动子，其中包含的响应元件，从而显示的重要性，启动子上下文的核受体的反式激活。
Retinoic acid transcriptionally regulate growth hormone (GH) gene expression through sequences located in the 5′ -flanking region of the gene. A partial induction by retinoic acid was obtained with the −181 bp of the rat GH promoter, and sequences up to −209 were required for a full response. These sequences contain the previously identified thyroid hormone responsive element. The retinoid X receptor RXR increased transactivation by T3 and RA. The retinoid was relatively more effective in stimulating the native GH promoter than an heterologous promoter which contains the response element, thus showing the importance of the promoter context on transactivation by the nuclear receptors.