Gluttony and thermogenesis revisited
Gluttony and thermogenesis revisited
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DOI：
10.1038/sj.ijo.0801108
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发表时间：
1999-11-01
影响因子：
4.9
通讯作者：
Stock, MJ
中科院分区：
文献类型：
--
作者：
Stock, MJ
本文综述了适应性、稳态产热形式的进化和生物学意义。在总结了产热在体温调节（寒战产热和非寒战产热）和感染发热反应（发热）中的作用和选择价值后，本文重点介绍了饮食诱导产热（DIT）。动物研究表明，DIT的进化主要是为了应对营养缺乏或不平衡的饮食，对1967年至1999年间进行的12项过度喂养研究的重新分析表明，人类可能也是如此，特别是当饮食蛋白质浓度变化时。这表明DIT在调节能量平衡中的作用是次要的，其调节必需营养素的代谢供应的功能。然而，当高蛋白或低蛋白饮食过量时，DIT的个体差异更为明显，这可以为区分代谢方面有抵抗力的人和易患肥胖的人提供一种非常敏感的方法。
The evolutionary and biological significance of adaptive, homeostatic forms of heat production (thermogenesis) is reviewed. After summarizing the role and selective value of thermogenesis in body temperature regulation (shivering and non-shivering thermogenesis) and the febrile response to infection (fever), the review concentrates on diet-induced thermogenesis (DIT). Animal studies indicate that DIT evolved mainly to deal with nutrient-deficient or unbalanced diets, and re-analysis of twelve overfeeding studies carried out between 1967 and 1999 suggests the same may be so for humans, particularly when dietary protein concentration is varied. This implies that the role of DIT in the regulation of energy balance is secondary to its function in regulating the metabolic supply of essential nutrients. However, individual differences in DIT are much more marked when high- or low-protein diets are overfed, and this could provide a very sensitive method for discriminating between those who are, in metabolic terms, resistant and those who are susceptible to obesity.