RELEASE OF FATTY ACID-BINDING PROTEIN FROM ISOLATED RAT-HEART SUBJECTED TO ISCHEMIA AND REPERFUSION OR TO THE CALCIUM PARADOX
RELEASE OF FATTY ACID-BINDING PROTEIN FROM ISOLATED RAT-HEART SUBJECTED TO ISCHEMIA AND REPERFUSION OR TO THE CALCIUM PARADOX
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DOI：
10.1016/0005-2760(88)90141-5
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发表时间：
1988-07-01
期刊：
影响因子：
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通讯作者：
RENEMAN, RS
中科院分区：
文献类型：
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作者：
GLATZ, JFC;VANBILSEN, M;RENEMAN, RS
心脏脂肪酸结合蛋白（cFABP）和脂肪酸的释放从离体大鼠心脏在缺血后60分钟的再灌注和钙悖论（钙离子再入院后一段时间的Ca2+游离灌注）测量。Ca2+再入后（超过组织含量的50%）的cFABP总释放比缺血再灌注后（平均为组织含量的3%）的cFABP释放明显得多，但在这两种情况下，它与乳酸脱氢酶的释放密切相关。只有少量的长链脂肪酸（如果有的话）从心脏中释放出来。这些观察结果挑战了cFABP在所研究的病理生理条件下起脂肪酸缓冲作用的观点。
The release of cardiac fatty acid-binding protein (cFABP) and of fatty acids from isolated rat hearts was measured during both reperfusion following 60 min of ischemia and the calcium paradox (readmission of Ca2+ after a period of Ca2+-free perfusion). Total cFABP release was much more pronounced after Ca2+ readmission (over 50% of tissue content) than during post-ischemic reperfusion (on average, 3% of tissue content), but in both cases, it closely paralleled the release of lactate dehydrogenase. Only minor amounts of long-chain fatty acids, if any, were released from the heart. These observations are challenging the idea that cFABP plays a fatty acid-buffering role under the pathophysiological conditions studied.