Environmental persistence of Tulane virus - a surrogate for human norovirus
Environmental persistence of Tulane virus - a surrogate for human norovirus
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DOI：
10.1139/cjm-2015-0756
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发表时间：
2016-05-01
影响因子：
2.8
通讯作者：
Gibson, Kristen Elizabeth
中科院分区：
文献类型：
--
作者：
Arthur, Sabastine Eugene;Gibson, Kristen Elizabeth
人类诺如病毒（HuNoV）是全球急性病毒性胃肠炎的主要原因。 HuNoV 在环境中的持续存在对其向人类的传播做出了重大贡献。由于缺乏该病毒的细胞培养系统，替代病毒被用来研究 HuNoV。在此，研究了杜兰病毒 (TV)（一种新型 HuNoV 替代品）在地表水 (SW) 和地下水 (GW) 以及丙烯酸基固体 (ABS) 和不锈钢 (SS) 表面上的持久性。 28 天后，到第 21 天，TV 在 SW 中保持稳定（GW 为 3.5 至 4 log(10)）。与 ABS 相比，TV 对 SS 的降低率更高，相应的 D 值分别为 18.5 +/- 0.34 和 13.1 +/- 0.36 天。这是第一项证明 TV 在环境水域和污染物表面上持久存在的研究。
Human noroviruses (HuNoVs) are the leading cause of acute viral gastroenteritis worldwide. The persistence of HuNoV in the environment contributes significantly to its transmission to humans. Surrogate viruses are used to study HuNoV owing to the lack of a cell culture system for this virus. Here, the persistence of Tulane virus (TV) - a novel HuNoV surrogate - in surface water (SW) and groundwater (GW) as well as on acrylic-based solid (ABS) and stainless steel (SS) surfaces was investigated. After 28 days, TV remained stable in SW (= 3.5 to 4 log(10) in GW by day 21. TV had a higher rate of reduction on SS compared with ABS, with corresponding D values of 18.5 +/- 0.34 and 13.1 +/- 0.36 days, respectively. This is the first study to demonstrate the persistence of TV in environmental waters and on fomite surfaces.