Relationship between epicardial adipose tissue volume measured using coronary computed tomography angiography and atherosclerotic plaque characteristics in patients with severe coronary artery stenosis
Relationship between epicardial adipose tissue volume measured using coronary computed tomography angiography and atherosclerotic plaque characteristics in patients with severe coronary artery stenosis
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DOI：
10.1177/0300060513496169
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发表时间：
2013-10-01
影响因子：
1.6
通讯作者：
Shen, Bao-Zhong
中科院分区：
文献类型：
--
作者：
Dong, Dan-Dan;Wang, Kai;Shen, Bao-Zhong
目的：为了探讨心外膜脂肪组织（EAT）体积和冠状动脉斑块composition.Methods之间的关系：EAT体积（测量冠状动脉CT血管造影）和冠状动脉斑块的特点进行了评估，每段的基础上（修改15段美国心脏病学会/美国心脏协会分类）在严重冠状动脉狭窄的患者。冠状动脉斑块分为四种类型：1、钙化斑块; 2、混合斑块（以钙化为主）; 3、混合斑块（以非钙化为主）; 4、非钙化斑块。结果：365例患者（平均年龄58.7 ± 8.0岁），EAT体积为169.85 ± 29.94 ml。患者特征无显著组间差异。观察到非钙化斑块组和钙化斑块组之间的EAT体积存在统计学显著差异。进食量与总胆固醇、低密度脂蛋白胆固醇呈正相关，与年龄、甘油三酯、体重指数、高密度脂蛋白胆固醇呈极弱相关。
Aim: To investigate the relationship between epicardial adipose tissue (EAT) volume and coronary plaque composition.Methods: EAT volume (measured using coronary computed tomography angiography) and coronary plaque characteristics were assessed on a per-segment basis (modified 15-segment American College of Cardiology/American Heart Association classification) in patients with severe coronary artery stenosis. Coronary plaques were classified into four types: 1, calcified plaques; 2, mixed plaques (calcification dominant); 3, mixed plaques (non-calcification dominant); and 4, non-calcified plaques. The gold standard for luminal stenosis was conventional coronary angiography.Results: In 365 patients (mean age 58.7 +/- 8.0 years), EAT volume was 169.85 +/- 29.94 ml. There were no significant between-group differences in patient characteristics. Statistically significant differences in EAT volume between non-calcified and calcified plaque groups were observed. EAT volume showed a positive correlation with total cholesterol and low-density-lipoprotein cholesterol, and a very weak correlation with age, triglyceride, body mass index and high-density-lipoprotein cholesterol.