Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
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人胰岛素瘤中视网膜母细胞瘤基因和维尔姆斯肿瘤基因的共同缺失以及 Krev-1 基因的重排。
DOI：
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发表时间：
1992
影响因子：
2.4
通讯作者：
Hideo Hayashi
中科院分区：
文献类型：
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作者：
Yukio Iwamura;Tsukasa Futagawa;Michio Kaneko;Kunio Nakagawa;Koichi Kawai;Kamejiro Yamashita;Tsutomu Nakamura;Hideo Hayashi
我们发现两个等位基因的视网膜母细胞瘤基因（Rb）和候选肾母细胞瘤基因（WT 33）在手术切除的人胰岛素瘤的印迹杂交缺失。在这种情况下，还检测到转化抑制基因Krev-1的重排。临床及组织学检查提示此肿瘤为良性胰岛素瘤。这一结果表明，多个肿瘤抑制基因的失活甚至可能参与人类良性肿瘤的发展。
We found deletions of both alleles of the retinoblastoma gene (Rb) and the candidate Wilms' tumor gene (WT33) in a surgically resected human insulinoma by blot hybridization. Rearrangement of Krev-1, a transformation suppressor gene, was also detected in this case. The clinical and histological findings suggested that this tumor would be a benign insulinoma. The result suggests that the inactivation of multiple tumor suppressor genes could be involved even in the development of benign human tumors.