The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen‐induced aggregation in man and the rat
The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen‐induced aggregation in man and the rat
复制标题
前列腺素内过氧化物、血栓素 A2 和二磷酸腺苷在人和大鼠胶原蛋白诱导聚集中的作用
DOI：
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发表时间：
1986
影响因子：
7.3
通讯作者：
G. P. Lewis
中科院分区：
文献类型：
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作者：
H. Emms;G. P. Lewis
1体外观察阿司匹林、羧基庚基咪唑(CHI)和肌酸磷酸/肌酸磷酸激酶(CP/CPK)对胶原诱导的血小板聚集和血栓素B2(TxB2)形成的影响。人类和大鼠两个物种的血小板已经被使用。2在MAN中，阿司匹林和CHI可抑制TxB2的产生，但仅部分抑制聚集。CP/CPK部分抑制TxB2的形成和聚集。3在大鼠中，阿司匹林和CHI可抑制TxB2的形成，但对聚集无影响。CP/CPK完全抑制聚集，部分抑制TxB2的生成。4在人中，胶原诱导的聚集在很大程度上依赖于ADP，在较小程度上依赖于花生四烯酸代谢产物，而在大鼠中，ADP单独介导该激动剂诱导的聚集。5 CP/CPK实验结果表明，TxB2的形成既依赖于先前释放的血小板ADP，也依赖于聚集本身，而不是参与聚集反应。
1 The effects of aspirin, carboxyheptylimidazole (CHI) and creatine phosphate/creatine phosphokinase (CP/CPK) on platelet aggregation and thromboxane B2 (TxB2) formation induced by collagen have been examined in vitro. Platelets from two species, man and the rat, have been used. 2 In man, aspirin and CHI abolished TxB2 production but only partially inhibited aggregation. CP/CPK partially inhibited aggregation and TxB2 formation. 3 In the rat, aspirin and CHI abolished TxB2 formation but had no effect on aggregation. CP/CPK completely inhibited aggregation and partially inhibited TxB2 generation. 4 In man, collagen‐induced aggregation is largely dependent on ADP and to a lesser extent on arachidonate metabolites whereas, in the rat, ADP alone mediates aggregation induced by this agonist. 5 The results with CP/CPK suggest that TxB2 formation is dependent either on the prior release of platelet ADP or on aggregation itself rather than being responsible for the aggregation response.