Metabolic heterogeneity of obesity: role of adipose tissue.
Metabolic heterogeneity of obesity: role of adipose tissue.
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DOI:
10.1038/ijosup.2012.3
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发表时间:
2012-07
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中科院分区:
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Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogenesis as leading theories as to why excess body weight has the potential to promote insulin resistance.