Dually emitting gold-silver nanoclusters as viable ratiometric fluorescent probes for cysteine and arginine
Dually emitting gold-silver nanoclusters as viable ratiometric fluorescent probes for cysteine and arginine
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双发射金银纳米团簇作为半胱氨酸和精氨酸的可行比率荧光探针
DOI：
10.1007/s00604-018-2674-0
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发表时间：
2018-01
影响因子：
5.7
通讯作者：
Song Gongwu
中科院分区：
文献类型：
--
作者：
Liu Mingwang;Li Na;He Yu;Ge Yili;Song Gongwu
采用一锅还原法制备了谷胱甘肽包被金/银纳米簇（GSH-Au/AgNCs），作为半胱氨酸（Cys）和精氨酸（Arg）的荧光纳米探针，对其他氨基酸具有良好的选择性。在360 nm激发下，GSH-Au/ agnc在616 nm和412 nm处有两个发射峰。随着Cys浓度的增加，在0.05 ~ 10 μM和10 ~ 50 μM的Cys浓度范围内，发射强度比值（I616/I412）呈线性降低。随着Arg浓度的增加，在Arg浓度为0 ~ 50 μM和50 ~ 100 μM范围内，I616/ i412的比值呈线性降低。该探针可用于血清和尿液加标样品中精氨酸和赖氨酸的测定，回收率高。摘要采用一锅还原法制备了谷胱甘肽包被金/银纳米团簇（GSH-Au/AgNCs），并发现它们是半胱氨酸（Cys）和精氨酸（Arg）的荧光纳米探针。
Glutathione coated gold and silver nanoclusters (GSH-Au/AgNCs) were synthesized by one-pot reduction methods and are found to be viable fluorescent nanoprobes for cysteine (Cys) and arginine (Arg), with good selectivity over other amino acids. The GSH-Au/AgNCs have two emissions at 616 nm and 412 nm when excited at 360 nm. With the increased concentration of Cys, the ratio of the emission intensities (I616/I412) linearly decreases with Cys in concentration ranging from 0.05 to 10 μM and from 10 to 50 μM, respectively. With increased concentrations of Arg, the ratio of I616/I412linearly decreases with Arg concentration ranging from 0 to 50 μM and from 50 to 100 μM, respectively. The probe was applied to the determination of Cys and Arg in spiked samples of serum and urine where it gave good recoveries.Graphical abstractGlutathione-coated gold and silver nanoclusters (GSH-Au/AgNCs) were synthesized by one-pot reduction and are found to be viable fluorescent nanoprobes for cysteine (Cys) and arginine (Arg).
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