Carbohydrate-deficient transferrin and γ-glutamyltransferase for the detection and monitoring of alcohol use:: Results from a multisite study
Carbohydrate-deficient transferrin and γ-glutamyltransferase for the detection and monitoring of alcohol use:: Results from a multisite study
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DOI：
10.1097/01.alc.0000023986.42254.f5
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发表时间：
2002-08-01
期刊：
影响因子：
--
通讯作者：
Tabakoff, B
中科院分区：
文献类型：
--
作者：
Anton, RF;Lieber, C;Tabakoff, B
背景：本文的目的是评价大量饮酒的生物学标志物--糖类缺乏性转铁蛋白(CDT)，并与更古老和更广泛使用的伽马-谷氨酰基转移酶(GGT)进行对比，以检测和监测重度饮酒。方法：通过一项大型多点研究，检测CDT和GGT对重度酒精摄入的敏感性和特异性，其中444例新入院的酒精者与204例社会饮酒者对照。结果：CDT和GGT在识别男性大量饮酒方面具有可比性，但GGT似乎更适合女性，无论男女，当这些标志物联合使用时，其灵敏度比单独使用时更高。禁食4周后，CDT和GGT均下降。当我们使用较基线戒断水平增加30%作为指标时，CDT在指示男性复发方面似乎略好于GGT，但在女性方面则不然。尤其对于男性，在研究过程中，通过同时评估两个标记物的变化(增加30%)可以最好地识别复发。结论：这些结果支持CDT的实用性，特别是当与GGT联合使用时。作为检测和监测大量饮酒的辅助手段。
Background: The purpose of this article is to evaluate the biological marker of heavy alcohol use, carbohydrate-deficient transferrin (CDT), in contrast to the older and more widely used gamma-glutamyltransferase (GGT) for the detection and monitoring of heavy alcohol use.Methods: In this report, CDT and GGT sensitivity and specificity for heavy alcohol intake are examined in a large multisite study in which 444 recently admitted inpatient alcoholics were compared with 204 matched social drinker controls. In addition, changes in these biomarkers were evaluated during an initial abstinence period and biweekly over 14 weeks of monitoring to compare changes in CDT and GGT during continued abstinence or relapse.Results: CDT and GGT were comparable in identifying heavy alcohol consumption in men, but GGT appeared to be better for women, For both genders, when these markers were combined, there was better sensitivity than when used alone. CDT and GGT both decreased during 4 weeks of abstinence. When we used a 30% increase from baseline abstinent levels as an indicator, CDT appeared marginally better than GGT at indicating relapse in men but not in women. For men in particular, relapse over the course of the study was best identified by evaluating changes (30% increase) in both markers simultaneously.Conclusions: These results support the utility, of CDT, especially when used in conjunction with GGT. as an aid in detecting and monitoring heavy alcohol consumption.