Effects of blood pump orientation on performance: In vitro assessment of universal advanced ventricular assist device.
Effects of blood pump orientation on performance: In vitro assessment of universal advanced ventricular assist device.
复制标题
血泵方向对性能的影响：通用先进心室辅助装置的体外评估。
DOI：
10.1111/aor.13690
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发表时间：
2020
影响因子：
2.4
通讯作者：
Karimov,JamshidH
中科院分区：
文献类型：
--
作者：
Miyamoto,Takuma;Kado,Yuichiro;Polakowski,AnthonyR;Horvath,DavidJ;Kuban,BarryD;Fukamachi,Kiyotaka;Karimov,JamshidH
我所正在开发的一种先进的心室辅助装置(VAD)具有特殊的功能，可以通过泵内压差改变轴向转子位置和泵性能。然而，由于重力对转子位置的影响，泵的方位会对性能产生影响。本研究的目的是评估泵的方位对泵性能的影响，包括泵停止时的脉冲压力和回流流量。VAD的台架测试是在带有气动装置的静态或脉动模拟环上进行的，以模拟自然脑室。在泵速分别为2000rpm、2500rpm、3000rpm和3500rpm时，从−90°(入口向上)到+90°(入口向下)从多个角度评价了泵的性能，包括压力-流量曲线、脉动度和返流流量。在+90°的所有转速下，泵的性能都略低于−90°。脉动模拟回路上的脉搏压力(80次/分)在没有泵支持的情况下为50毫米汞柱，在泵支持期间保持在50毫米汞柱，并且不受方位(−90°、0°和+90°)的影响。停泵时，各角度的返流流量均接近0 L/min。泵的方位对泵的性能影响不大，对停泵时的脉压和回流流量没有影响。这表明重力对转子总成的影响不大。
An advanced ventricular assist device (VAD), which is under development in our institution, has specific features that allow changes in the axial rotor position and pump performance by intrapump pressure difference. However, performance could be influenced by the pump orientation because of the effect of gravity on the rotor position. The purpose of this study was to evaluate the effects of pump orientation on the pump performance, including pulse pressure and regurgitant flow through the pump when the pump was stopped. Bench testing of the VAD was performed on a static or pulsatile mock loop with a pneumatic device to simulate the native ventricle. The pump performance, including pressure–flow curve, pulsatility, and regurgitant flow, was evaluated at several angles, ranging from −90° (inlet pointed upward) to +90° (inlet pointed downward) at pump speeds of 2000, 2500, 3000, and 3500 rpm. The pump performance was slightly lower at +90° at all rotational speeds, compared with −90°. The pulse pressure on the pulsatile mock loop (80 bpm) was 50 mm Hg without pump support, remained at 50 mm Hg during pump support, and was not changed by orientation (−90°, 0°, and +90°). When the pump was stopped, the regurgitant flow was near 0 L/min at all angles. Pump orientation had a minor effect on pump performance, with no effect on pulse pressure or regurgitant flow when the pump was stopped. This indicates that the effect of gravity on the rotor assembly is insignificant.