Abnormalities of motor timing in Huntington's disease.
Abnormalities of motor timing in Huntington's disease.
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DOI：
10.1016/1353-8020(96)00009-0
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发表时间：
1996-04-01
影响因子：
4.1
通讯作者：
Snowden, J S
中科院分区：
文献类型：
--
作者：
Freeman, J S;Cody, F W;Snowden, J S
研究了亨廷顿舞蹈病（HD）患者和对照组受试者在听觉信号指示的目标频率（1-5 Hz）下产生有节奏的手指敲击运动的能力，以及在突然退出提示后维持敲击速度的能力。在有线索和没有线索的情况下，高清表现的特点是：(i)瞬时敲击率明显不规则；（ii）在较高（3-5 Hz）频率目标上敲击太慢，而在低频率目标上敲击太快。使用Wing和Kristofferson的电机定时模型（Wing AM, Kristofferson AB.感知器），在1.8 Hz的目标频率下，分析无信号敲击过程中敲击间隔的变化。Psychophys。1973;（14:5 -12），表明了HD中假设的“时钟”和“运动实现”系统的干扰。
The ability of patients with Huntington's disease (HD) and control subjects to produce rhythmic finger tapping movements at target frequencies (1-5 Hz) signalled by auditory cues, and to sustain the tapping tempo following sudden withdrawal of cues, was investigated. HD performance, in both the presence and absence of cues, was characterised by, (i) marked irregularity of instantaneous tapping rates and (ii) a tendency to tap too slowly at higher (3-5 Hz) frequency targets and too rapidly at low target frequencies. Analysis of the variability of inter-tap intervals, during uncued tapping at a target rate of 1.8 Hz, using Wing and Kristofferson's model of motor timing (Wing AM, Kristofferson AB. Percept. Psychophys. 1973; 14: 5-12), indicated disturbances of both hypothetical 'clock' and 'motor implementation' systems in HD.