Association between LGR4 polymorphisms and peak bone mineral density and body composition
Association between LGR4 polymorphisms and peak bone mineral density and body composition
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DOI：
10.1007/s00774-020-01106-0
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发表时间：
2020-05-12
影响因子：
3.3
通讯作者：
Zhang，Zhen-Lin
中科院分区：
文献类型：
--
作者：
Yu，Wei-Jia;Zhang，Zeng;Zhang，Zhen-Lin
富含亮氨酸重复序列的G蛋白偶联受体4（LGR 4）可通过增强Wnt/β-catenin信号通路影响成骨细胞的分化和骨量。LGR 4也与糖脂代谢有关。本研究旨在探讨LGR 4基因的遗传变异与中国核心家系峰值骨密度（peak bone mineral density，peak BMD）和体成分表型的关系。采用双能X线骨密度仪（DXA）测量身体成分（瘦体重和脂肪量）和峰值BMD。结果在1000个变异后的QTDT分析中，rs 11029986位点与总脂肪量（TFM）和总脂肪百分比（PFM）有显著的家族内关联。（分别为P= 0.014和0.011）、rs 12787344、rs 4128868、rs 4923445和rs7936621和体重指数（BMI）rs 11029986和全髋BMD（P = 0.026），rs 12796247、rs 2219783和腰椎BMD（P= 0.013和0.027）。单倍型GCGT和AAGC（均在第3区）与BMI有显著的家族内关联（P= 0.003和0.002，respectively.ConclusionIt is the first family based association analysis to explore and demonstrate significant association between LGR 4 genotype and variations of peak BMD and body composition in young men.这一结果与近年来的研究结果相一致，证实了LGR 4基因与骨密度和体成分之间的重要关系。
IntroductionLeucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) could affect differentiation of osteoblasts and bone mass through potentiating Wnt/β-catenin signaling. LGR4 is also relevant to glycolipid metabolism. The present study aims to explore the relationship between genetic variations inLGR4gene and peak bone mineral density (peak BMD) and body composition phenotypes in Chinese nuclear families.Materials and methods22 single-nucleotide polymorphisms (SNPs) were selected and five blocks were constructed inLGR4. Body composition (lean mass and fat mass) and peak BMD were measured by dual-energy X-ray absorptiometry (DXA). Quantitative transmission disequilibrium test (QTDT) analysis was used to explore the relationship betweenLGR4genotypes and the mentioned phenotypes.ResultsFor QTDT analysis after 1000 permutations, significant within-family associations were observed between rs11029986 and total fat mass (TFM) and percentage of TFM (PFM) (P= 0.014 and 0.011, respectively), rs12787344, rs4128868, rs4923445, and rs7936621 and body mass index (BMI) (P= 0.008, 0.003, 0.046, and 0.003, respectively), rs11029986 and total hip BMD (P= 0.026), and rs12796247, rs2219783, and lumbar spine BMD (P= 0.013 and 0.027, respectively). Haplotypes GCGT and AAGC (both in block 3) were observed in significant within-family association with BMI (P= 0.003 and 0.002, respectively).ConclusionIt is the first family-based association analysis to explore and demonstrate significant associations betweenLGR4genotypes and variations of peak BMD and body composition in young Chinese men. The results are consistent with the findings that recent studies revealed, and confirm the critical relationship betweenLGR4gene and both BMD and body composition.