Mechanical consequence of trabecular bone loss and its treatment: A three-dimensional model simulation
Mechanical consequence of trabecular bone loss and its treatment: A three-dimensional model simulation
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DOI：
10.1016/s8756-3282(01)00673-1
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发表时间：
2002-02-01
期刊：
影响因子：
4.1
通讯作者：
Kim, CH
中科院分区：
文献类型：
--
作者：
Guo, XE;Kim, CH
骨小梁微结构的增龄性变化，如骨小梁数量和骨小梁厚度的减少。导致机械性能的降低，如杨氏模数和强度。目前的药物治疗，如双磷酸盐或甲状旁腺激素，主要是通过增加骨小梁厚度而不是增加骨小梁数量来改善骨的力学性能。然而，这些治疗的机械效果还没有完全用松质骨模型来量化。在本研究中，我们使用理想化的骨小梁三维(3D)微结构模型，通过骨小梁变薄或随机去除骨小梁来造成骨丢失，并通过增加剩余骨小梁的骨小梁厚度来模拟治疗。由于骨小梁丢失导致的杨氏模数或强度的降低与骨体积分数的减少的力量比由于骨小梁变薄而减少的力量要大得多。这表明由于骨小梁丢失而导致的骨丢失对松质骨的杨氏模数和强度的损害比由于骨小梁变薄造成的损害更大，这说明了骨小梁的数量和连通性在骨小梁的力学完整性中的重要性。一般而言，即使骨丢失完全恢复，通过增加骨小梁丢失后剩余骨小梁厚度的方法也不能完全恢复完整骨的初始力学性能，而骨小梁增厚可以完全恢复骨小梁变薄后的力学性能。结果还表明，力学性能的残余损失与小梁损失的程度有关。(bone 30：404-411；2002)(C)2002，Elsevier Science Inc.版权所有。
Age-related changes in the microstructure of trabecular bone, such as decreases in trabecular number and trabecular thickness. lead to reductions in mechanical properties, such as Young's modulus and strength. Current drug therapy, such as bisphosphonate or parathyroid hormone, improves the mechanical properties of bone mainly by increasing the trabecular thickness, but not increasing the trabecular number. However, the mechanical efficacy of these treatments has not been fully quantified using trabecular bone models. In this study, we used an idealized three-dimensional (3D) microstructural model of trabecular bone to create bone loss either through trabeculae thinning or random removal of trabeculae, and simulated treatment by increasing the trabeculae thickness of the remaining trabeculae. The reduction in either the Young's modulus or the strength due to trabeculae loss was proportional to a much higher power of reduction in bone volume fraction than due to trabeculae thinning. This indicates that bone loss due to trabeculae loss is much more detrimental to Young's modulus and strength of trabecular bone than due to trabeculae thinning, indicating the importance of trabecular number and connectivity in the mechanical integrity of trabecular bone. In general, treatments by increasing the trabecular thickness of remaining trabeculae after trabeculae loss cannot fully recover the initial mechanical properties of intact bone, even if bone loss is fully recovered, whereas trabecular thickening can fully restore the mechanical properties after bone loss by trabeculae thinning. The results also show that the residual loss in mechanical properties is dependent on the extent of trabeculae loss. (Bone 30:404-411; 2002) (C) 2002 by Elsevier Science Inc. All rights reserved.