CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes.
CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes.
复制标题
CRH 介导成人表皮角质形成细胞中脂多糖诱导的炎症。
DOI：
10.1038/sj.jid.5700607
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Slominski,AndrzejT
中科院分区：
文献类型：
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作者：
Zbytek,Blazej;Slominski,AndrzejT
促肾上腺皮质激素释放激素 (CRH) 是一种 41 个氨基酸的肽，是系统反应的主要调节剂，可在中枢水平抑制免疫反应（Chrousos 和 Gold，1992）。在包括表皮在内的外周部位，CRH 充当有效的促炎剂（Karalis 等，1991；Theoharides 等，2004；Slominski 等，2006a，b）。在正常角质形成细胞中，CRH 激活炎症的主调节因子 NF-κB (Zbytek et al., 2004) 并刺激 ICAM-1 和 HLA-DR 的表达 (Quevedo et al., 2001)。表皮角质形成细胞参与各种应激源引发的炎症反应 (Barker et al., 1991)。细菌通过 Toll 样受体 (TLR)-2 和 TLR-4 诱导正常角质形成细胞产生炎症细胞因子 (Nagy et al., 2005)。因此，需要对人类角质形成细胞中细菌、CRH 和炎症细胞因子之间的联系进行功能研究。
Corticotropin-releasing hormone (CRH), a 41-amino-acid peptide, is a main regulator of the systemic response that suppresses immune response on a central level (Chrousos and Gold, 1992). In the peripheral sites, including the epidermis, CRH acts as potent proinflammatory agent (Karalis et al., 1991; Theoharides et al., 2004; Slominski et al., 2006a, b). In normal keratinocytes, CRH activates the master regulator of inflammation NF-κB (Zbytek et al., 2004) and stimulates the expression of ICAM-1 and HLA-DR (Quevedo et al., 2001).Epidermal keratinocytes take part in inflammatory responses initiated by various stressors (Barker et al., 1991). Induction of production of inflammatory cytokines in normal keratinocytes by bacteria occurs via toll-like receptor (TLR)-2 and TLR-4 (Nagy et al., 2005). Therefore, there is a need for the functional study of the link between bacteria, CRH, and inflammatory cytokines in human keratinocytes.