Clinical Data of Neonatal Systemic Thrombosis
Clinical Data of Neonatal Systemic Thrombosis
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DOI：
10.1016/j.jpeds.2015.12.035
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发表时间：
2016-04-01
影响因子：
5.1
通讯作者：
Simioni, Paolo
中科院分区：
文献类型：
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作者：
Saracco, Paola;Bagna, Rossana;Simioni, Paolo
目的探讨新生儿非脑系统性静脉血栓栓塞（VT）、动脉血栓栓塞（AT）和心内血栓栓塞（ICT）的临床资料及相关危险因素。研究设计75例新生儿首次发生系统性血栓栓塞的资料分析（0-28天），2007年1月至2013年7月期间从儿科中心纳入意大利儿科血栓登记处。41例（55%）为VT，22例（29%）为AT，12例（16%）为ICT;男性占65%，71%为早产。19例（25%）在出生后第一天诊断为血栓栓塞。在这个“早发性”组中，70%报告了产前相关风险状况（母体/胎盘疾病），33%报告了遗传性血栓形成倾向。73%存在产后风险因素;感染和中心血管导管分别在56%和54%的VT中，67%的ICT和27%的AT中（
Objective To evaluate clinical data and associated risk conditions of noncerebral systemic venous thromboembolism (VT), arterial thromboembolism (AT), and intracardiac thromboembolism (ICT) in neonates.Study design Data analysis of first systemic thromboembolism occurring in 75 live neonates (0-28 days), enrolled in the Italian Registry of Pediatric Thrombosis from neonatology centers between January 2007 and July 2013.Results Among 75 events, 41 (55%) were VT, 22 (29%) AT, and 12 (16%) ICT; males represented 65%, and 71% were preterm. In 19 (25%), thromboembolism was diagnosed on the first day of life. In this "early onset" group, prenatal-associated risk conditions (maternal/placental disease) were reported in 70% and inherited thrombophilia in 33%. Postnatal risk factors were present in 73%; infections and central vascular catheters in 56% and 54% VT, respectively, and in 67% ICT vs 27% AT (