FUT2 secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.
FUT2 secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.
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DOI：
10.12688/wellcomeopenres.14636.2
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发表时间：
2018
影响因子：
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通讯作者：
Timpson NJ
中科院分区：
文献类型：
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作者：
Azad MB;Wade KH;Timpson NJ
背景：FUT 2（岩藻糖基转移酶-2）基因决定血型分泌状态。作为无活性的“非分泌”rs601338（A）等位基因的纯合子赋予对某些感染（例如诺如病毒、轮状病毒）的抗性和对其他感染（例如流感嗜血杆菌、肺炎链球菌）的易感性。非分泌型也有1型糖尿病和炎症性肠病的风险增加。我们在基于人群的队列中检查了FUT 2基因型、感染和慢性疾病。 方法：我们研究了来自ALSPAC妊娠队列的7,582名孕妇。感染（麻疹、腮腺炎、水痘、百日咳、脑膜炎、疱疹、淋病和泌尿系统感染）和慢性疾病（肾脏疾病、高血压、糖尿病、风湿病、关节炎、牛皮癣、花粉热、哮喘、湿疹和过敏）是自我报告的。根据rs601338基因型确定FUT 2分泌状态。从临床记录中获得ABO血型。 结果：总的来说，1920名妇女（25.3%）是纯合子的非分泌等位基因（AA）。分泌型状态与腮腺炎相关，68%的非分泌型患者经历了这种感染，而分泌型患者为48%（RR，1.40; 95%CI，1.34-1.46）。麻疹感染的相关性较弱（76% vs. 72%; RR，1.05; 95% CI，1.02-1.09）。非分泌型患者的肾脏疾病风险也增加（5.4% vs. 3.9%; RR，1.39; 95% CI，1.11-1.75）。与分泌型无关，AB型是腮腺炎的危险因素（与O型相比，RR为1.15; 95%CI为1.03，1.28）。我们没有发现分泌状态和血型之间相互作用的证据。 对于某些疾病，包括哮喘和关节炎，FUT 2杂合性（GA）似乎赋予中间表型。没有强有力的证据表明分泌状态与其他感染或慢性疾病之间存在关联，尽管罕见结果的统计功效有限。 结论：我们的研究结果确定了FUT 2分泌状态和自我报告的肾脏疾病之间的关联，并证实了最近报道的与腮腺炎感染易感性的关联。这些关联的临床意义需要进一步研究。
Background: The FUT2 (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive “non-secretor” rs601338(A) allele confers resistance to certain infections (e.g. Norovirus, Rotavirus) and susceptibility to others (e.g. Haemophilus influenza, Streptococcus pneumonia). Non-secretors also have an increased risk of type 1 diabetes and inflammatory bowel disease. We examined FUT2 genotype, infections and chronic conditions in a population-based cohort. Methods: We studied 7,582 pregnant women from the ALSPAC pregnancy cohort. Infections (measles, mumps, chicken pox, whooping cough, meningitis, herpes, gonorrhea and urinary infections) and chronic conditions (kidney disease, hypertension, diabetes, rheumatism, arthritis, psoriasis, hay fever, asthma, eczema and allergies) were self-reported. FUT2 secretor status was determined from the rs601338 genotype. ABO blood type was obtained from clinical records. Results: Overall, 1920 women (25.3%) were homozygous for the non-secretor allele (AA). Secretor status was associated with mumps, with 68% of non-secretors experiencing this infection, compared to 48% of secretors (RR, 1.40; 95% CI, 1.34–1.46). A weaker association was observed for measles infection (76% vs. 72%; RR, 1.05; 95% CI, 1.02–1.09). Non-secretors also experienced an increased risk of kidney disease (5.4% vs. 3.9%; RR, 1.39; 95% CI, 1.11–1.75). Independent of secretor status, AB blood type was a risk factor for mumps (RR 1.15; 95%CI, 1.03, 1.28 compared to type O). We found no evidence of interaction between secretor status and blood type. For some conditions, including asthma and arthritis, FUT2 heterozygosity (GA) appeared to confer an intermediate phenotype. There was no strong evidence of association between secretor status and other infections or chronic conditions, although statistical power was limited for rare outcomes. Conclusion: Our results identify an association between FUT2 secretor status and self-reported kidney disease, and confirm a recently reported association with susceptibility to mumps infection. The clinical implications of these associations warrant further investigation.