Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults.
Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults.
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DOI：
10.4049/immunohorizons.2000104
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发表时间：
2021-06-28
期刊：
影响因子：
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通讯作者：
Knoop KA
中科院分区：
文献类型：
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作者：
Greenfield KG;Badovinac VP;Griffith TS;Knoop KA
脓毒症可由多种病原体引起，其来源多种多样。 “菌血症”这个笼统的术语包含了各种各样的症状，这使得诊断和预后特别麻烦。导致不同结果的一个尚未充分研究的因素是患者的年龄。极低出生体重婴儿的新生儿败血症可导致与成人败血症截然不同的免疫结果。从临床前实验模型和临床观察来看，越来越清楚的是，年龄和既往微生物暴露史可以显着影响从脓毒症和细胞因子风暴到免疫病理学的感染过程。在这项研究中，我们将探讨新生儿和成人脓毒症之间的主要区别、用于研究脓毒症的实验模型，以及对周围微生物宇宙的反应如何塑造免疫系统的发育以及对病程产生积极或消极的影响。
Sepsis can result from a variety of pathogens, originating from a range of sources. A vast range of presenting symptoms is included in the catch-all term of “bacteremia,” making diagnosis and prognosis particularly troublesome. One underexplored factor contributing to disparate outcomes is the age of the patient. Neonatal sepsis in very-low-birth-weight infants can result in vastly different immunological outcomes unique from sepsis in adults. It is also becoming increasingly clear, both from preclinical experimental models and clinical observations, that the age and history of previous microbial exposures can significantly influence the course of infection from sepsis and cytokine storms to immunopathology. In this study, we will explore key differences between neonatal and adult sepsis, experimental models used to study sepsis, and how responses to the surrounding microbial universe shape development of the immune system and impact, positively or negatively, the course of disease.