Effect of silicone oil on macular capillary vessel density and thickness
Effect of silicone oil on macular capillary vessel density and thickness
复制标题
硅油对黄斑毛细血管密度和厚度的影响
DOI：
10.3892/etm.2019.8243
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发表时间：
2020-01-01
影响因子：
2.7
通讯作者：
Zhang, Shaochong
中科院分区：
文献类型：
--
作者：
Xiang, Wu;Wei, Yantao;Zhang, Shaochong
本研究评估了复杂玻璃体视网膜手术后与眼硅油填充（SOT）相关的黄斑毛细血管密度和厚度的变化。共23例接受玻璃体切除联合玻璃体内SOT的患者回顾性入组，每例参与者均进行单眼评估。此外，纳入了20例需要硅油取出（SOR）的患者。采用光学相干断层扫描血管造影（optical coherence tomography angiography，OCTA）分析黄斑区毛细血管密度和黄斑中心凹无血管区（fovealavascularzone，FAZ）面积，OCT测量视网膜厚度。结果表明，SOT后黄斑区浅层毛细血管丛（superior capillary plexus，SCP）和深层毛细血管丛（deepcapillary plexus，DCP）的毛细血管密度、FAZ面积和全视网膜厚度保持在稳定水平（P>0.05），与SOR组比较差异无显著性（P>0.05）。此外，SOT组的视网膜旁（P=0.008）、上半侧（P=0.007）、颞侧（P=0.015）、上级（P=0.028）和鼻侧（P=0.002）内层视网膜厚度均降低，而SOR后内层视网膜厚度与基线相比无变化（P>0.05）。总之，硅油在6个月内对黄斑毛细血管密度没有显著影响，但可能会压缩和减少内层视网膜的厚度。
The present study assessed changes in macular capillary vessel density and thickness associated with ocular silicone oil tamponade (SOT) following complex vitreoretinal surgery. A total of 23 patients who underwent pars plana vitrectomy combined with intravitreal SOT were retrospectively enrolled, and a single eye was assessed in each participant. Furthermore, 20 patients who required silicone oil removal (SOR) were included. The macular capillary vessel density and the foveal avascular zone (FAZ) area were analyzed using optical coherence tomography angiography (OCTA) and retinal thickness was assessed by OCT. The results demonstrated that the macular capillary vessel density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), the FAZ area and full retinal thickness were retained at a stable level following SOT (P>0.05), and also following SOR (P>0.05). Furthermore, the parafoveal (P=0.008), superior-hemi (P=0.007), temporal (P=0.015), superior (P=0.028) and nasal (P=0.002) inner retinal thickness decreased in the SOT group, whereas the inner retinal thickness was unaltered after SOR vs. baseline (P>0.05). In conclusion, silicone oil has no significant effect on macular capillary vessel density within a 6-month period but may compress and reduce the thickness of the inner retina.