Epicardial conductors can lower the defibrillation threshold in rabbit hearts.
Epicardial conductors can lower the defibrillation threshold in rabbit hearts.
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DOI：
10.1109/tbme.2008.2005067
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Knisley Ast SB
中科院分区：
文献类型：
--
作者：
Sims JA;Knisley Ast SB
在除颤电击过程中，心外膜导体由于降低了导体下心肌组织的电压梯度而产生抗刺激效应，而由于边缘附近的膜极化而产生刺激效应。我们假设，增加导体的面积会增加除颤阈值(DFT)，而增加导体的刺激边缘数量会降低DFT。为了测试这一点，我们测量了带和不带矩形导体组的兔心的DFT，这些矩形导体组的面积为250或500 mm2，边缘长度垂直于与电击电极相交的线的长度为100、200或400 mm。与以前的报告中导体增加或不改变DFT不同，本研究结果表明，面积为250 mm2、边缘为200 mm的导体几何形状降低了DFT。这一结果与导体边缘的刺激效应可以增强除颤冲击效果的假设是一致的。
During a defibrillation shock, epicardial conductors can introduce anti-stimulatory effects due to lowering of the voltage gradient in myocardial tissue under the conductor and stimulatory effects due to membrane polarization near edges. We hypothesized that increasing the area of conductors increases the defibrillation threshold (DFT), while increasing the amount of stimulatory edge of conductors decreases the DFT. To test this, we measured the DFT in excised rabbit hearts with and without sets of rectangular conductors having 250 or 500 mm2 area and 100, 200 or 400 mm length of edges perpendicular to the line intersecting the shock electrodes. Unlike previous reports in which conductors increased or did not change DFT, present results indicate a conductor geometry having area of 250 mm2 and edge of 200 mm decreases the DFT. This result is consistent with the hypothesis that stimulatory effects of the edge of a conductor can enhance defibrillation shock efficacy.