IL-17 cytokines in immunity and inflammation.
IL-17 cytokines in immunity and inflammation.
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DOI:
10.1038/emi.2013.58
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发表时间:
2013-09
影响因子:
13.2
通讯作者:
Dong, Chen
中科院分区:
文献类型:
--
作者:
Jin, Wei;Dong, Chen
Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In this review, we summarize the recent findings in IL-17 biology and the progress towards understanding the regulatory mechanisms of IL-17 expression and signaling mechanisms. This knowledge will benefit the development of novel immune modulators that enhance immunity to various infections and reduce inflammatory damage in infected patients.
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