Hospitalization, major complications and mortality in acute myocardial infarction patients during the COVID-19 era: A systematic review and meta-analysis.

Hospitalization, major complications and mortality in acute myocardial infarction patients during the COVID-19 era: A systematic review and meta-analysis.
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DOI:
10.1016/j.ijcha.2022.101058
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发表时间:
2022-08
影响因子:
2.9
通讯作者:
Azari, Samad
Azari, Samad
中科院分区:
其他
文献类型:
--
作者:
Pourasghari, Hamid;Tavolinejad, Hamed;Soleimanpour, Samira;Abdi, Zhaleh;Arabloo, Jalal;Bragazzi, Nicola Luigi;Behzadifar, Masoud;Rashedi, Sina;Omidi, Negar;Ayoubian, Ali;Tajdini, Masih;Ghorashi, Seyyed Mojtaba;Azari, Samad

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自SARS-CoV-2大流行开始以来,许多研究报告了急性心肌梗死(AMI)入院人数的下降。在本系统综述和荟萃分析中,我们的目的是比较大流行期间AMI入院率和主要并发症,与大流行前相比。检索了三个主要数据库(PubMed、Scopus和Web of Science Core Collection)。在314篇文章中,41篇被纳入研究。与大流行前相比,新冠肺炎时代因AMI住院的患者减少了35%,具有统计学显著性(OR = 0.65; 95%CI:0.56-0.74; I2 = 99%; p < 0.001; 28项研究)。与COVID-19之前的时期相比,COVID-19时代因STEMI和NSTEMI住院的患者分别减少了29%和34%,这在统计学上具有显著性(OR = 0.71; 95% CI:0.65 - 0.78; I2 = 93%; p < 0.001; 22项研究,OR = 0.66; 95% CI:0.58-0.73; I2 = 95%; p < 0.001; 14项研究)。新冠肺炎时代,AMI患者的总体院内死亡率增加了26%,但没有统计学意义(OR = 1.26; 95%CI:1.0-1.59; I2 = 22%; p < 0.001; 6项研究)。STEMI和NSTEMI患者的住院死亡率在COVID-19时代分别增加了15%和26%,这在统计学上并不显著(OR = 1.15; 95% CI:0.85-1.57; I2 = 48%; p = 0.035; 11项研究,OR = 1.35; 95% CI:0.64-2.86; I2 = 45%; p = 0.157; 3篇文章)。这些观察结果突显了医疗系统在适应COVID-19疫情影响方面的挑战。
Since the SARS-CoV-2 pandemic began, numerous studies have reported a concerning drop in the number of acute myocardial infarction (AMI) admissions. In the present systematic review and meta-analysis, we aimed to compare the rate of AMI admissions and major complication during the pandemic, in comparison with pre-pandemic periods. Three major databases (PubMed, Scopus, and Web of Science Core Collection) were searched. Out of 314 articles, 41 were entered into the study. Patients hospitalized for AMI were 35% less in the COVID-19 era compared with pre-pandemic periods, which was statistically significantly (OR = 0.65; 95% CI: 0.56–0.74; I2 = 99%; p < 0.001; 28 studies). Patients hospitalized for STEMI and NSTEMI were 29% and 34% respectively less in the COVID-19 era compared with periods before COVID-19, which was statistically significantly (OR = 0.71; 95% CI: 0.65 –0.78; I2 = 93%; p < 0.001; 22 studies, OR = 0.66; 95% CI: 0.58–0.73; I2 = 95%; p < 0.001; 14 studies). The overall rate of in-hospital mortality in AMI patients increased by 26% in the COVID-19 era, which was not statistically significant (OR = 1.26; 95% CI: 1.0–1.59; I2 = 22%; p < 0.001; six studies). The rate of in-hospital mortality in STEMI and NSTEMI patients increased by 15% and 26% respectively in the COVID-19 era, which was not statistically significant (OR = 1.15; 95% CI: 0.85–1.57; I2 = 48%; p = 0.035; 11 studies, OR = 1.35; 95% CI: 0.64–2.86; I2 = 45%; p = 0.157; 3 articles). These observations highlight the challenges in the adaptation of health-care systems with the impact of the COVID-19 pandemic.
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