Age‐related microstructural changes in subcortical white matter during postadolescent periods in men revealed by diffusion‐weighted MR imaging
Age‐related microstructural changes in subcortical white matter during postadolescent periods in men revealed by diffusion‐weighted MR imaging
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DOI：
10.1002/hbm.20738
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发表时间：
2009-10
影响因子：
4.8
通讯作者：
T. Yoshiura;T. Noguchi;A. Hiwatashi;O. Togao;K. Yamashita;Tomohiro Nakao;E. Nagao;S. Kumazawa;H. Arimura;H. Honda
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文献类型：
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作者：
T. Yoshiura;T. Noguchi;A. Hiwatashi;O. Togao;K. Yamashita;Tomohiro Nakao;E. Nagao;S. Kumazawa;H. Arimura;H. Honda
青春期后脑白质（WM）的持续成熟尚不完全清楚。为了阐明大脑 WM 可能发生的青春期后成熟变化的时间过程和位置，我们使用弥散加权成像研究了 60 名 20 岁至 70 岁的健康男性受试者。使用自动化方法测量每个受试者大脑 78 个皮质区域的皮层下 WM 平均扩散率 (MD)。回归分析用于通过每个区域的线性或二次函数来模拟 MD 的年龄相关变化。皮层下 MD 的年龄相关变化最好通过 27 个区域的线性函数或二次函数来建模，包括语言相关区域、双侧枕叶和颞叶的视觉或多模态区域、包括双侧海马旁回的边缘区域以及双侧中央后回和左侧中央前回。在这些地区，MD 迅速下降，直到中年，然后达到稳定水平。我们的结果揭示了局部皮层下 WM 的微观结构变化，并表明青春期后的持续成熟过程。 Hum Brain Mapp 2009。© 2009 Wiley-Liss, Inc.
Continuous maturation of cerebral white matter (WM) in the postadolescent period is not fully understood. To elucidate the time course and location of possible postadolescent maturational changes in cerebral WM, we studied 60 healthy male subjects who were in their second to seventh decade using diffusion‐weighted imaging. Mean diffusivity (MD) in subcortical WM was measured in 78 cortical regions in each subject's brain using an automated method. Regression analysis was used to model the age‐related change in MD by either a linear or a quadratic function in each region. Age‐related changes in subcortical MD were best modeled by either a linear function or a quadratic function in 27 regions including language‐related regions, visual or multimodal areas in the bilateral occipital and temporal lobes, limbic areas including the bilateral parahippocampal gyri, and the bilateral postcentral and left precentral gyri. In these regions, the MD rapidly decreased until middle age and thereafter reached a plateau. Our results revealed microstructural changes in local subcortical WM and suggests a continuing maturational process in postoadolescent periods. Hum Brain Mapp 2009. © 2009 Wiley‐Liss, Inc.