Neuronal activity in nucleus ambiguus during deglutition and vocalization in conscious monkeys
Neuronal activity in nucleus ambiguus during deglutition and vocalization in conscious monkeys
复制标题
清醒猴子吞咽和发声过程中模糊核的神经元活动
DOI：
--
复制
发表时间：
1994
影响因子：
2
通讯作者：
P. Kahrilas
中科院分区：
文献类型：
--
作者：
G. Chiao;Charles R. Larson;Y. Yajima;P. Ko;P. Kahrilas
细胞外记录了三只有意识的猕猴在自发发声和吞咽时的模糊核。通过与类甲状腺肌电图（EMG）活动的相关性推断神经元活动与吞咽的时间关系。第四只猴子在吞咽含钡果汁时的视频透视分析建立了吞咽和类甲状腺素肌电活动之间的时间关系。从模糊核及其邻近区域记录的691个细胞中，80个细胞的神经元活动在吞咽过程中表现出调节。62个细胞被归类为“活跃”细胞，与吞咽相关的活性增加，而18个细胞被归类为“抑制”细胞，与吞咽相关的滋补活性降低。在这些细胞开始调节和吞咽开始之间有一个连续的潜伏期，从吞咽开始前的“早”到吞咽开始后的“晚”，大多数细胞（44个细胞）在吞咽开始时显示调节。62个与吞咽相关的活跃细胞中的大多数（37个）也发出声音，但它们在吞咽过程中表现出较低的放电频率和较长的爆发持续时间。在18个抑制的吞咽相关细胞中，有11个细胞随呼吸周期周期性排出，可能是腹侧髓质呼吸中枢的一部分。这种长期清醒的灵长类动物模型将保留许多可能改变口咽吞咽的感觉输入，并可能更好地接近人类生理学。
Extracellular recordings were made from the nucleus ambiguus in three conscious Macaca nemestrina monkeys during spontaneous vocalizations and swallows. The temporal relationship of neuronal activity to swallowing was inferred through correlation with the thyroarytenoid electromyographic (EMG) activity. Videofluoroscopic analysis of a fourth monkey during swallows of barium-impregnated fruit juice established the temporal relationship between swallowing and thyroarytenoid EMG activity. Of 691 cells recorded from the nucleus ambiguus and its adjacent area, the neuronal activity of 80 cells showed modulation during swallowing. Sixty-two cells were classified as “active” cells, with increased activity in relation to swallowing, while 18 cells were classified as “suppressed” cells, with tonic activity that reduced with swallowing. A continuum of latency was seen between the onset of modulation of these cells and the onset of swallowing, from “early” before the swallow to “late” after the swallow onset with most of the cells (44 cells) showing modulation near the onset of the swallow. A majority (37) of the 62 active swallowing-related cells also discharged with vocalization, but they demonstrated a lower discharge frequency and a longer burst duration during swallowing. Of the 18 suppressed swallowing-related cells, 11 cells discharged phasically with the respiratory cycle and may be a part of the ventral medullary respiratory center. This chronic awake primate model would preserve the many sensory inputs that may modify the oropharyngeal swallow and may better approximate human physiology.
呼吸暂停和喉部刺激引起的其他呼吸模式期间的呼吸神经元活动。
DOI：
10.1152/jappl.1991.70.6.2742
发表时间：
1991
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Lawson,EE;Richter,DW;Czyzyk-Krzeska,MF;Bischoff,A;Rudesill,RC
通讯作者：
Rudesill,RC
用于吞咽视频放射学研究生物力学分析的交互式计算机程序。
DOI：
10.2214/ajr.153.2.277
发表时间：
1989
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Logemann,JA;Kahrilas,PJ;Begelman,J;Dodds,WJ;Pauloski,BR
通讯作者：
Pauloski,BR