Calculated fast-growing benign prostatic hyperplasia -: A risk factor for developing clinical prostate cancer
Calculated fast-growing benign prostatic hyperplasia -: A risk factor for developing clinical prostate cancer
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DOI：
10.1080/003655902320783827
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发表时间：
2002-11-30
影响因子：
--
通讯作者：
Högstedt, B
中科院分区：
文献类型：
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作者：
Hammarsten, J;Högstedt, B
目的：良性前列腺增生（BPH）的发生与临床前列腺癌之间是否存在关联尚存在争议。本报告通过检查最近发现的患有缓慢或快速生长的 BPH 临床前列腺癌的男性的分期、分级和 PSA 水平，检验了 BPH 生长与临床前列腺癌发展之间关联的假设。如果该假设成立，患有快速生长的 BPH 的男性将患有更晚期的临床前列腺癌。材料和方法：连续纳入了 220 名被诊断为临床前列腺癌的患者。动脉粥样硬化性疾病、非胰岛素依赖型糖尿病（NIDDM）或已治疗高血压的患病率由各患者的病史提供。测定身高、体重、腰围、臀围和血压。计算体重指数（BMI）和腰臀比（WHR）。抽取血样测定甘油三酯、总胆固醇、HDL-胆固醇、LDL-胆固醇、尿酸、ALAT 和空腹血浆胰岛素水平。使用经直肠超声测量前列腺体积。假设患者 40 岁时前列腺总体积为 20 mL，计算 BPH 年增长率。前列腺癌的诊断是采用经直肠超声引导下的前列腺自动穿刺活检技术进行的。结果：患有临床前列腺癌的男性，PSA
Objective: Whether there is an association between the development of benign prostatic hyperplasia (BPH) and clinical prostate cancer is controversial. The present report tests the hypothesis of an association between BPH growth and the development of clinical prostate cancer by examining stage, grade and PSA-level in men with recently discovered clinical prostate cancer with slow or fast-growing BPH. If the hypothesis is true, men with fast-growing BPH would have a more advanced clinical prostate cancer.Material and Methods: Two hundred and twenty patients in whom a clinical prostate cancer was diagnosed were consecutively included. The prevalence of atherosclerotic disease, non-insulin-dependent diabetes mellitus (NIDDM) or treated hypertension was provided by the respective patient's medical history. Tallness, body weight, waist measurement, hip measurement and blood pressure were determined. The body mass index (BMI) and waist/hip ratio (WHR) were calculated. Blood samples were drawn to determine triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, ALAT and the fasting plasma insulin level. The prostate gland volume was measured using transrectal ultrasound. The annual BPH growth rate was calculated, assuming that the total prostate gland volume was 20 mL at the patient age of forty. The prostate cancer diagnosis was established using the technique of transrectal ultrasound-guided automatic needle biopsy of the prostate.Results: Men with clinical prostate cancer, PSA