A new pleiotropic effect of statins in elderly: modulation of telomerase activity
A new pleiotropic effect of statins in elderly: modulation of telomerase activity
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DOI：
10.1096/fj.13-232066
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发表时间：
2013-09-01
期刊：
影响因子：
4.8
通讯作者：
Paolisso, Giuseppe
中科院分区：
文献类型：
--
作者：
Boccardi, Virginia;Barbieri, Michelangela;Paolisso, Giuseppe
Recent evidence suggests a link between statins and telomere biology. Whether statin treatment may modulate telomerase activity and affect telomere erosion rate is unknown. We aimed at investigating the potential impact of statin therapy on peripheral blood mononuclear cells telomerase activity, its implication on LTL variability, and its association with telomere shortening rates along with aging. The cross-sectional study was conducted in 230 subjects (age range: 30-86 y) stratified according to statins treatment. LTL was measured by quantitative polymerase chain reaction and telomerase activity by a PCR-ELISA protocol. Subjects on statin treatment showed higher telomerase activity (P
