The Need for New Approaches to Antimalarial Chemotherapy
The Need for New Approaches to Antimalarial Chemotherapy
复制标题
抗疟化疗新方法的需求
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
L. Miller
中科院分区：
文献类型：
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作者：
P. Rosenthal;L. Miller
数千年来，疟疾一直是人类痛苦的一个主要原因，尽管我们对这一疾病的了解取得了重要进展，但它仍然是世界上严重疾病和死亡的最大原因之一。具有讽刺意味的是，在令人兴奋的科学进步为成功管理许多以前无法治愈的疾病提供机会的时候，我们可靠地治疗疟疾的能力在过去的半个世纪里实际上已经减弱。目前，有一些抗疟药物可用，但其使用受到高成本、毒性和寄生虫抗药性增加的限制。因此，迫切需要最佳利用现有药物，并开发新的抗疟化疗方法。
Malaria has been a major cause of human suffering for thousands of years, and despite important advances in our understanding of the disease, it continues to be one of the greatest causes of serious illness and death in the world. Ironically, at a time when exciting scientific advances are offering the opportunity to successfully manage many previously untreatable diseases, our ability to reliably treat malaria has actually diminished over the last half-century. At present, a number of antimalarial drugs are available, but their use is limited by high cost, toxicity, and increasing parasite resistance. Thus, there is a great need for the optimal use of available drugs and the development of new approaches to antimalarial chemotherapy.