Testosterone, gonadotropin, and cortisol secretion in male patients with major depression
Testosterone, gonadotropin, and cortisol secretion in male patients with major depression
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DOI：
10.1097/00006842-199905000-00007
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发表时间：
1999-05-01
影响因子：
3.3
通讯作者：
Heuser, I
中科院分区：
文献类型：
--
作者：
Schweiger, U;Deuschle, M;Heuser, I
目的：以往关于抑郁症患者性激素水平的研究结果不一致。然而，在抑郁症中看到的下丘脑-垂体-肾上腺系统的激活可能在每个调节水平上对性腺功能产生负面影响。本研究的目的是探讨是否严重抑郁发作确实与性腺功能的改变。研究方法：在24小时内频繁取样，对15名中度至高度严重的男性抑郁症住院患者和22名健康对照受试者（年龄范围22-85岁）的睾酮、脉冲性LH分泌、FSH和皮质醇进行了评估。结果如下：协方差模型分析显示，在仅校正年龄后，抑郁症男性住院患者的日间睾酮（p < .01）、夜间睾酮（p < .05）和24小时平均睾酮分泌（p < .01）显著降低。抑郁症患者LH脉冲频率也有下降的趋势（p <0.08）。结论：性腺功能可能会受到干扰的男性抑郁发作的中度至高度的严重性。
Objective: Previous studies of sex hormone concentrations in depression yielded inconsistent results. However, the activation of the hypothalamic-pituitary-adrenal system seen in depression may negatively affect gonadal function at every level of regulation. The objective of this study was to explore whether major depressive episodes are indeed associated with an alteration of gonadal function. Methods: Testosterone, pulsatile LH secretion, FSH, and cortisol were assessed using frequent sampling during a 24-hour period in 15 male inpatients with major depression of moderate to high severity and in 22 healthy comparison subjects (age range 22-85 years). Results: An analysis of covariance model showed that after adjustment for age only, daytime testosterone (p < .01), nighttime testosterone (p < .05), and 24-hour mean testosterone secretion (p < .01) were significantly lower in the depressed male inpatients. There was also a trend for a decreased LH pulse frequency in the depressed patients (p < .08). Conclusions: Gonadal function may be disturbed in men with a depressive episode of moderate to high severity.