Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.
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DOI：
10.1152/physrev.00022.2011
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发表时间：
2012-07
影响因子：
33.6
通讯作者：
Tschöp MH
中科院分区：
文献类型：
--
作者：
Nogueiras R;Habegger KM;Chaudhary N;Finan B;Banks AS;Dietrich MO;Horvath TL;Sinclair DA;Pfluger PT;Tschöp MH
Sirtuins是一个高度保守的依赖NAD+的脱乙酰酶家族，作为细胞传感器来检测能量供应和调节代谢过程。哺乳动物sirtuin 1(SIRT1)和sirtuin 3(SIRT3)是控制代谢过程的两个核心sirtuin，它们分别定位于细胞核和线粒体。两者都被高NAD+水平激活，这是一种由低细胞能量状态引起的情况。SIRT1和SIRT3通过去乙酰化诱导分解代谢过程的多种蛋白质，同时抑制合成代谢过程，协调增加细胞能量储存，最终维持细胞能量平衡。SIRT1和SIRT3控制的信号转导通路的缺陷会导致多种代谢紊乱。因此，通过遗传或药物手段激活sirtuins可以产生多种代谢益处，保护小鼠免受饮食诱导的肥胖、2型糖尿病和非酒精性脂肪性肝病的影响。
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria, respectively. Both are activated by high NAD+ levels, a condition caused by low cellular energy status. By deacetylating a variety of proteins that induce catabolic processes while inhibiting anabolic processes, SIRT1 and SIRT3 coordinately increase cellular energy stores and ultimately maintain cellular energy homeostasis. Defects in the pathways controlled by SIRT1 and SIRT3 are known to result in various metabolic disorders. Consequently, activation of sirtuins by genetic or pharmacological means can elicit multiple metabolic benefits that protect mice from diet-induced obesity, type 2 diabetes, and nonalcoholic fatty liver disease.
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影响因子：
29
作者：
Bai P;Canto C;Brunyánszki A;Huber A;Szántó M;Cen Y;Yamamoto H;Houten SM;Kiss B;Oudart H;Gergely P;Menissier-de Murcia J;Schreiber V;Sauve AA;Auwerx J
通讯作者：
Auwerx J
影响因子：
4.8
作者：
Al-Regaiey, KA;Masternak, MM;Bartke, A
通讯作者：
Bartke, A
DOI：
10.1152/ajpgi.90358.2008
发表时间：
2008-10-01
影响因子：
4.5
作者：
Ajmo, Joanne M.;Liang, Xiaomei;You, Min
通讯作者：
You, Min
影响因子：
4.8
作者：
Amat, Ramon;Planavila, Anna;Villarroya, Francesc
通讯作者：
Villarroya, Francesc
影响因子：
7.7
作者：
Ayala, JE;Streeper, RS;O'Brien, RM
通讯作者：
O'Brien, RM