Template images for nonhuman primate neuroimaging: 2. Macaque
Template images for nonhuman primate neuroimaging: 2. Macaque
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DOI：
10.1006/nimg.2001.0871
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发表时间：
2001-09-01
期刊：
影响因子：
5.7
通讯作者：
Perlmutter, JS
中科院分区：
文献类型：
--
作者：
Black, KJ;Koller, JM;Perlmutter, JS
神经影像学研究越来越多地在猕猴物种中进行，包括长尾猕猴（Macaca nemestrina）。有时，实验问题可以通过分析单个受试者的功能图像和参考该受试者的结构图像来回答。然而，跨多个受试者的功能性脑图像的共配准提供了对多个受试者进行基于体素的分析的实验优势，因此被广泛用于人类研究。基于体素的共配准方法需要高质量的3D模板图像。我们创建了这样的模板，来源于12只nemestrina猴子的t1加权MRI和血流PET图像。我们设计了猕猴模板，以最大限度地与同伴论文中描述的狒狒模板图像兼容，以促进跨物种功能成像数据的比较。本文给出的数据显示了图像自动配准到模板的可靠性和有效性。即使跨物种，所选内部基准点的对齐也精确到总体（平均）1.9 mm以内。模板图像，以及与加州大学洛杉矶分校nemestrina脑图谱对齐的副本，可以在互联网（purl.org/net/kbmd/n2k）上获得，并且可以作为任何图像配准软件的目标。(C) 2001学术出版社。
Neuroimaging studies are increasingly performed in macaque species, including the pig-tailed macaque (Macaca nemestrina). At times experimental questions can be answered by analysis of functional images in individual subjects and reference to a structural image in that subject. However, coregistration of functional brain images across many subjects offers the experimental advantage of enabling voxel-based analysis over multiple subjects and is therefore widely used in human studies. Voxel-based coregistration methods require a high-quality 3D template image. We created such templates, derived from T1-weighted MRI and blood-flow PET images from 12 nemestrina monkeys. We designed the macaque templates to be maximally compatible with the baboon template images described in a companion paper, to facilitate cross-species comparison of functional imaging data. Here we present data showing the reliability and validity of automatic image registration to the template. Alignment of selected internal fiducial points was accurate to within 1.9 mm overall (mean) even across species. The template images, along with copies aligned to the UCLA nemestrina brain atlas, are available on the Internet (purl.org/net/kbmd/n2k) and can be used as targets with any image registration software. (C) 2001 Academic Press.