The hibernating male golden hamster as a model for studying homologue pairing, chiasma formation and disjunction during spermatogenesis.
The hibernating male golden hamster as a model for studying homologue pairing, chiasma formation and disjunction during spermatogenesis.
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冬眠的雄性金仓鼠作为研究精子发生过程中同源配对、交叉形成和分离的模型。
DOI：
10.1095/biolreprod35.4.1037
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发表时间：
1986
影响因子：
3.6
通讯作者：
Wertheim,I
中科院分区：
文献类型：
--
作者：
Jagiello,GM;Fang,JS;Sung,WK;Ducayen,MB;Wertheim,I
虽然许多研究试图了解染色体配对和遗传重组的机制，但哺乳动物卵子发生和精子发生的数据很少。在这里报道的实验中，冬眠的雄性金黄地鼠的精子发生被用来测试在寒冷中冬眠对这个物种减数分裂的一些基本方面的影响。研究表明，这种生理状态可导致脱氧核糖核酸（DNA）合成的前细线期持续时间增加、二价配对异常、交换减少和染色体不分离增加。这些数据为进一步研究雄性哺乳动物的这些遗传现象提供了有用的证据。
Although many studies have been made in an attempt to understand the mechanisms of chromosome pairing and genetic recombination, data on mammalian oogenesis and spermatogenesis are sparse. In the experiments reported here, spermatogenesis of the hibernating male golden hamster was used to test the effect of hibernation in the cold on some essential aspects of meiosis in this species. It was demonstrated that this physiologic state can result in increased duration of preleptotene synthesis of deoxyribonucleic acid (DNA), abnormalities in bivalent pairing, reduced crossing-over, and increased chromosomal nondisjunction. These data provide evidence of the usefulness of this model for further studies of these genetic phenomena in a male mammal.