Embryo cryopreservation and utilization in the United States from 2004-2013.
Embryo cryopreservation and utilization in the United States from 2004-2013.
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DOI：
10.1016/j.xfre.2020.05.010
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发表时间：
2020-09
期刊：
影响因子：
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通讯作者：
Polotsky AJ
中科院分区：
文献类型：
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作者：
Christianson MS;Stern JE;Sun F;Zhang H;Styer AK;Vitek W;Polotsky AJ
评估2004年至2013年在美国辅助生殖技术(ART)诊所冷冻保存的胚胎的数量和使用情况，并描述所有胚胎都被冷冻保存的ART周期的趋势。回顾分析。不适用。来自辅助生殖技术学会的注册数据。2004至2013年间，向辅助生殖技术协会临床结果报告系统报告的美国ART周期的历史队列。冷冻保存胚胎的数量和与冷冻保存胚胎相关的因素。2010年后，所有胚胎被冷冻的新鲜周期的百分比每年都在急剧增加：15.6%(2010年)、19.9%(2011年)、30.7%(2012年)和40.7%(2013年)。在10年的时间里，1954,548枚胚胎被冷冻保存，717,345枚胚胎被移植。在2004年至2013年的纯冷冻周期中，卵巢储备减少的女性比例(19.9%至34.1%)和使用植入前基因检测的女性比例(3.2%至6.9%)显著增加。在10年期间，有294,575个新鲜周期进行了胚胎移植，至少有一个胚胎被冷冻保存。总体而言，52.5%(n=154,543)没有进行后续的冷冻胚胎移植，29.5%(n=40,462)没有冷冻胚胎，50.4%(n=68,875)有1-5个胚胎，20.0%(n=27,396)有≥6。与胚胎过多相关的因素包括捐赠者的卵母细胞周期和安提米勒激素水平的增加。在美国，所有胚胎都被冷冻的ART周期急剧增加，这可能会导致更多的胚胎被储存。
To evaluate the quantity and use of embryos cryopreserved at assisted reproductive technology (ART) clinics in the United States from 2004 through 2013 and to characterize trends in ART cycles in which all embryos were cryopreserved. Retrospective analysis. Not applicable. Registry data from the Society for Assisted Reproductive Technology. Historical cohort of U.S. ART cycles reported to the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System between 2004 and 2013. Number of embryos cryopreserved and factors associated with having cryopreserved embryos. The percentage of fresh cycles in which all embryos were frozen increased dramatically each year after 2010: 15.6% (2010), 19.9% (2011), 30.7% (2012), and 40.7% (2013). During 10 years, 1,954,548 embryos were cryopreserved and 717,345 embryos were transferred. In freeze-only cycles from 2004 to 2013, there was a significant increase in the percentage of women with diminished ovarian reserve (19.9% to 34.1%) and in those who used preimplantation genetic testing (3.2% to 6.9%). During the 10-year period, there were 294,575 fresh cycles with embryo transfer and at least one embryo cryopreserved. Overall, 52.5% (n = 154,543) did not undergo a subsequent frozen embryo transfer, 29.5% (n = 40,462) were left with no frozen embryos, 50.4% (n = 68,875) had one–five embryos, and 20.0% (n = 27,396) had ≥six. Factors associated with having excess embryos included donor oocyte cycles and increased antimüllerian hormone levels. There has been a sharp increase in U.S. ART cycles in which all embryos are frozen and this may result in more embryos in storage.