Multiple muscarinic receptors in the CNS. Significance and prospects for future research.
Multiple muscarinic receptors in the CNS. Significance and prospects for future research.
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中枢神经系统中有多种毒蕈碱受体。
DOI：
10.1016/0006-2952(86)90001-8
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发表时间：
1986
影响因子：
5.8
通讯作者：
MesserJr,W
中科院分区：
文献类型：
--
作者：
Hoss,W;MesserJr,W
Muscarinic cholinergic receptors, which are located primarily on smooth muscle and in the CNS, appear to consist, at least on the basis of molecular weight, of only one or two peptides [l, 21. The receptors are linked through GTP-binding proteins to second messenger systems that mediate the various cholinergic responses. The final common endpoint of receptor occupancy is the regulation of protein kinases, which have the capacity to alter various membrane conductances by the phosphorylation of specific proteins.A dynamic multisubunit structure for receptors provides the opportunity for elaborate control over their characteristics and, thus, functions. This raises the possibility of “isoreceptors”, similar to isoenzymes, which contain subunits coded by different genes, leading to distinct characteristics for each isotype. The possibility of receptor isotypes leads to a fundamental question: Do the apparent subtypes of muscarinic receptors represent different conformational states of the same entity, different peptides, or both? The isolation and characterization of muscarinic receptors are expected to shed light on this question.
